Design, synthesis and effect of triazole derivatives against some toxic activities of Bothrops jararaca venom
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DOI: 10.1007/s00044-020-02653-x
Abstract: According to the World Health Organization, snakebite envenoming is a neglected disease that affects around 5.4 million people worldwide each year. In Brazil, in 2019 there were 29,000 cases of accidents, with 104 deaths. The… read more here.
Keywords: design synthesis; effect triazole; protocol; jararaca venom ... See more keywords
Abstract A60: Full-length transcripts identification from deep transcriptomic analysis of Bothrops jararaca venom gland
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DOI: 10.1158/1557-3265.tcm17-a60
Abstract: Introduction: Head and neck cancer is a collective term defined by topographic and anatomic features to describe malignant tumors of the upper aerodigestive tract. Despite the different strategies used in the treatment of head and… read more here.
Keywords: venom gland; full length; jararaca venom; length transcripts ... See more keywords
Revisiting the Therapeutic Potential of Bothrops jararaca Venom: Screening for Novel Activities Using Connectivity Mapping
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DOI: 10.3390/toxins10020069
Abstract: Snake venoms are sources of molecules with proven and potential therapeutic applications. However, most activities assayed in venoms (or their components) are of hemorrhagic, hypotensive, edematogenic, neurotoxic or myotoxic natures. Thus, other relevant activities might… read more here.
Keywords: connectivity; revisiting therapeutic; jararaca venom; bothrops jararaca ... See more keywords
Extracellular Vesicles from Bothrops jararaca Venom Are Diverse in Structure and Protein Composition and Interact with Mammalian Cells
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DOI: 10.3390/toxins14110806
Abstract: Snake venoms are complex cocktails of non-toxic and toxic molecules that work synergistically for the envenoming outcome. Alongside the immediate consequences, chronic manifestations and long-term sequelae can occur. Recently, extracellular vesicles (EVs) were found in… read more here.
Keywords: jararaca venom; extracellular vesicles; bothrops jararaca; evs ... See more keywords
Cationic PLGA Nanoparticle Formulations as Biocompatible Immunoadjuvant for Serum Production and Immune Response against Bothrops jararaca Venom
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DOI: 10.3390/toxins14120888
Abstract: Snakebite envenoming represents a worldwide public health issue. Suitable technologies have been investigated for encapsulated recombinant or native proteins capable of inducing an effective and long-lasting adaptive immune response. Nanoparticles are colloidal dispersions that have… read more here.
Keywords: jararaca venom; bothrops jararaca; immune response; production ... See more keywords