A novel partial de novo duplication of JARID2 gene causing a neurodevelopmental phenotype
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.2037
Abstract: Deletions covering the entire or partial JARID2 gene as well as pathogenic single nucleotide variants leading to haploinsufficiency of JARID2 have recently been shown to cause a clinically distinct neurodevelopmental syndrome. Here, we present a… read more here.
Keywords: jarid2; novo duplication; partial novo; duplication jarid2 ... See more keywords
1014 - THE PRC2 CO-FACTOR JARID2 IS A KEY REGULATOR OF NORMAL AND NEOPLASTIC HEMATOPOIESIS
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.252
Abstract: The property of self-renewal sustains the hematopoietic stem cell (HSC) pool for the lifetime of an organism. While tremendous progress has been made into understanding specific genes and pathways that regulate HSC self-renewal, the molecular… read more here.
Keywords: factor jarid2; self renewal; hematopoiesis; jarid2 ... See more keywords
Nucleation and propagation of heterochromatin by the histone methyltransferase PRC2: geometric constraints and impact of the regulatory subunit JARID2.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b02321
Abstract: Polycomb Repressive Complex 2 (PRC2) catalyzes mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27me1-3) to control expression of genes important for differentiation and maintenance of cell identity. PRC2 activity is regulated by… read more here.
Keywords: nucleation propagation; jarid2; prc2 activity; prc2 ... See more keywords
Distinct binding pattern of EZH2 and JARID2 on RNAs and DNAs in hepatocellular carcinoma development
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.904633
Abstract: Hepatocellular carcinoma (HCC) is one of the most malignant cancers worldwide, with high mortality. However, the molecular regulatory mechanisms of liver cancer, especially transcriptional and post-transcriptional mechanisms, should be further studied. Here we used chromatin… read more here.
Keywords: development; jarid2; rnas dnas; carcinoma ... See more keywords
Function of JARID2 in bovines during early embryonic development
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DOI: 10.7717/peerj.4189
Abstract: Histone lysine modifications are important epigenetic modifications in early embryonic development. JARID2, which is a member of the jumonji demethylase protein family, is a regulator of early embryonic development and can regulate mouse development and… read more here.
Keywords: cell; embryonic development; jarid2; expression ... See more keywords