Synthesis of jaspine B regioisomers through palladium-catalyzed stereoselective tetrahydrofuran formation: Insight into the ligand recognition of sphingosine kinases
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.02.042
Abstract: Abstract We recently reported a structure-activity relationship study of 4-epi-jaspine B derivatives toward sphingosine kinase (SphK) and identified selective inhibitors of two SphK isoforms. In this study, we designed and synthesized jaspine B regioisomers on… read more here.
Keywords: tetrahydrofuran formation; palladium catalyzed; jaspine; jaspine regioisomers ... See more keywords
Methuosis Contributes to Jaspine-B-Induced Cell Death
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DOI: 10.3390/ijms23137257
Abstract: Methuosis is a type of programmed cell death in which the cytoplasm is occupied by fluid-filled vacuoles that originate from macropinosomes (cytoplasmic vacuolation). A few molecules have been reported to behave as methuosis inducers in… read more here.
Keywords: cell death; cytoplasmic vacuolation; cell; jaspine ... See more keywords