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   Articles with "jat" as a keyword



Sensitive Detection and Visual Recognition of Jatrorrhizine Based on a Fluorescent Eu Coordination Polymer Probe

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recommendations! Published in 2024 at "Applied Organometallic Chemistry"

DOI: 10.1002/aoc.7800

Abstract: Based on 4‐([2,2′:6′,2″‐terpyridin]‐4′‐yl) benzoic acid ligand (Htpba), a fluorescent lanthanide coordination polymer was successfully synthesized, namely, [Eu (tpba)3]n (1). The single‐crystal diffraction analysis shows that Eu3+ ions in complex 1 are alternately connected with tpba3−… read more here.

Keywords: detection; jat; coordination polymer; jatrorrhizine ... See more keywords

Jatrorrhizine ameliorates Schwann cell myelination via inhibiting HDAC3 ability to recruit Atxn2l for regulating the NRG1‐ErbB2‐PI3K‐AKT pathway in diabetic peripheral neuropathy mice

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recommendations! Published in 2022 at "Phytotherapy Research"

DOI: 10.1002/ptr.7641

Abstract: Diabetic peripheral neuropathy (DPN) is a chronic complication associated with nerve dysfunction and uncontrolled hyperglycemia. Unfortunately, due to its complicated etiology, there has been no successful therapy for DPN. Our research recently revealed that jatrorrhizine… read more here.

Keywords: pi3k akt; erbb2 pi3k; myelination; nrg1 erbb2 ... See more keywords

Jatrorrhizine Alleviates Calcific Aortic Valve Disease via Interfering With Glycolysis Targeting ALDOA K42 Lactylation

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recommendations! Published in 2025 at "Phytotherapy Research"

DOI: 10.1002/ptr.8504

Abstract: Calcific aortic valve disease (CAVD) is a common cardiovascular disorder. It is characterized by the thickening, fibrosis, and mineralization of aortic valve leaflets. These pathological changes can progress to heart failure if not managed effectively.… read more here.

Keywords: jat; valve; lactylation; aortic valve ... See more keywords

Jatrorrhizine inhibits colorectal carcinoma proliferation and metastasis through Wnt/β-catenin signaling pathway and epithelial–mesenchymal transition

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recommendations! Published in 2019 at "Drug Design, Development and Therapy"

DOI: 10.2147/dddt.s207315

Abstract: Purpose Jatrorrhizine (JAT) is a natural protoberberine alkaloid, possesses detoxification, bactericidal and hypoglycemic activities. However, its anti-cancer mechanism is not clear. This study aimed to investigate the mechanism of JAT through which inhibits colorectal cancer… read more here.

Keywords: inhibits colorectal; metastasis; cancer; proliferation ... See more keywords

Jatrorrhizine Improves Endothelial Function in Diabetes and Obesity through Suppression of Endoplasmic Reticulum Stress

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms232012064

Abstract: Jatrorrhizine (JAT) is one of the major bioactive protoberberine alkaloids found in rhizoma coptidis, which has hypoglycemic and hypolipidemic potential. This study aimed to evaluate the vasoprotective effects of JAT in diabetes and obesity and… read more here.

Keywords: endoplasmic reticulum; stress; reticulum stress; mouse aortas ... See more keywords