A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvz263
Abstract: Abstract Aims Genome-wide association studies (GWAS) have consistently identified an association between coronary artery disease (CAD) and a locus on chromosome 10 containing a single gene, JCAD (formerly KIAA1462). However, little is known about the… read more here.
Keywords: gene jcad; coronary artery; jcad; atherosclerosis ... See more keywords
JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study.
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DOI: 10.1093/eurheartj/ehac641
Abstract: AIMS Variants of the junctional cadherin 5 associated (JCAD) locus associate with acute coronary syndromes. JCAD promotes experimental atherosclerosis through the large tumor suppressor kinase 2 (LATS2)/Hippo pathway. This study investigates the role of JCAD… read more here.
Keywords: pi3k akt; promotes arterial; jcad; arterial thrombosis ... See more keywords
83 The coronary artery disease associated gene JCAD regulates hippo signalling in endothelial cells
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DOI: 10.1136/heartjnl-2018-bcs.83
Abstract: Genome-wide association studies have associated a large number of loci with coronary artery disease (CAD) risk. The CAD-associated variants at 10 p11.23 fall in JCAD, which encodes an endothelial junction protein. We set out to investigate… read more here.
Keywords: jcad knockdown; hippo signalling; endothelial cells; jcad ... See more keywords
Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease–Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo
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DOI: 10.1161/atvbaha.117.309721
Abstract: Objective— Recent genome-wide association studies newly identified the human KIAA1462 gene as a new locus for coronary artery disease. However, the function of the gene product, named JCAD (junctional protein associated with coronary artery disease),… read more here.
Keywords: coronary artery; mice; jcad; artery disease ... See more keywords