A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvz263
Abstract: Abstract Aims Genome-wide association studies (GWAS) have consistently identified an association between coronary artery disease (CAD) and a locus on chromosome 10 containing a single gene, JCAD (formerly KIAA1462). However, little is known about the… read more here.
Keywords: gene jcad; coronary artery; jcad; atherosclerosis ... See more keywords
JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study.
Sign Up to like & getrecommendations! Published in 2022 at "European heart journal"
DOI: 10.1093/eurheartj/ehac641
Abstract: AIMS Variants of the junctional cadherin 5 associated (JCAD) locus associate with acute coronary syndromes. JCAD promotes experimental atherosclerosis through the large tumor suppressor kinase 2 (LATS2)/Hippo pathway. This study investigates the role of JCAD… read more here.
Keywords: pi3k akt; promotes arterial; jcad; arterial thrombosis ... See more keywords
83 The coronary artery disease associated gene JCAD regulates hippo signalling in endothelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Heart"
DOI: 10.1136/heartjnl-2018-bcs.83
Abstract: Genome-wide association studies have associated a large number of loci with coronary artery disease (CAD) risk. The CAD-associated variants at 10 p11.23 fall in JCAD, which encodes an endothelial junction protein. We set out to investigate… read more here.
Keywords: jcad knockdown; hippo signalling; endothelial cells; jcad ... See more keywords
Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease–Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2017 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.117.309721
Abstract: Objective— Recent genome-wide association studies newly identified the human KIAA1462 gene as a new locus for coronary artery disease. However, the function of the gene product, named JCAD (junctional protein associated with coronary artery disease),… read more here.
Keywords: coronary artery; mice; jcad; artery disease ... See more keywords
JCAD deficiency attenuates activation of hepatic stellate cells and cholestatic fibrosis
Sign Up to like & getrecommendations! Published in 2024 at "Clinical and Molecular Hepatology"
DOI: 10.3350/cmh.2023.0506
Abstract: Background/Aims Cholestatic liver diseases including primary biliary cholangitis (PBC) are associated with active hepatic fibrogenesis, which ultimately progresses to cirrhosis. Activated hepatic stellate cells (HSCs) are the main fibrogenic effectors in response to cholangiocyte damage.… read more here.
Keywords: mice; jcad; fibrosis; hepatic stellate ... See more keywords
Loss of JCAD/KIAA1462 Protects the Lung from Acute and Chronic Consequences of Chronic Obstructive Pulmonary Disease
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25179492
Abstract: Even with recent advances in pathobiology and treatment options, chronic obstructive pulmonary disease (COPD) remains a major contributor to morbidity and mortality. To develop new ways of combating this disease, breakthroughs in our understanding of… read more here.
Keywords: disease; loss; chronic obstructive; kiaa1462 ... See more keywords