Serum IgG antibodies from healthy subjects up to 100 years old react to JC polyomavirus
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26457
Abstract: JC polyomavirus (JCPyV) was identified in 1971 in the brain tissue of a patient (J.C.) affected by the progressive multifocal leukoencephalopathy (PML). JCPyV encodes for the oncoproteins large T antigen (Tag) and small t‐antigen (tag).… read more here.
Keywords: serum; jcpyv vp1; healthy subjects; igg antibodies ... See more keywords
Footprints of BK and JC polyomaviruses in specimens from females affected by spontaneous abortion
Sign Up to like & getrecommendations! Published in 2019 at "Human Reproduction"
DOI: 10.1093/humrep/dey375
Abstract: STUDY QUESTION Are JC polyomavirus (JCPyV) and BK polyomavirus (BKPyV) infections associated with spontaneous abortion (SA)? SUMMARY ANSWER There is no association of JCPyV or BKPyV with SA. WHAT IS KNOWN ALREADY A large number… read more here.
Keywords: spontaneous abortion; dna; 104 cells; jcpyv bkpyv ... See more keywords
A Difficult Decision: Atypical JC Polyomavirus Encephalopathy in a Kidney Transplant Recipient
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation"
DOI: 10.1097/tp.0000000000001275
Abstract: Background A number of cerebral manifestations are associated with JC polyomavirus (JCPyV) which are diagnosed by detection of JCPyV in cerebrospinal fluid (CSF), often with the support of cerebral imaging. Here we present an unusual… read more here.
Keywords: kidney transplant; allograft; polyomavirus; jcpyv ... See more keywords
Inhibition of JC polyomavirus infectivity by the retrograde transport inhibitor Retro‐2.1
Sign Up to like & getrecommendations! Published in 2020 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12851
Abstract: JC polyomavirus (JCPyV) is a common human pathogen that results in a chronic asymptomatic infection in healthy adults. Under conditions of immunosuppression, JCPyV spreads to the central nervous system and can cause the fatal demyelinating… read more here.
Keywords: retrograde transport; infection; infectivity; polyomavirus ... See more keywords
JC Polyomavirus Infection Reveals Delayed Progression of the Infectious Cycle in Normal Human Astrocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.01331-19
Abstract: Animal models are crucial in advancing biomedical research and defining the pathogenesis of human disease. Unfortunately, not all diseases can be easily modeled in a nonhuman host or such models are cost prohibitive to generate,… read more here.
Keywords: jcpyv; infection; jcpyv infection; cell ... See more keywords
ERK Is a Critical Regulator of JC Polyomavirus Infection
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01529-17
Abstract: ABSTRACT The human JC polyomavirus (JCPyV) infects the majority of the population worldwide and presents as an asymptomatic, persistent infection in the kidneys. In individuals who are immunocompromised, JCPyV can become reactivated and cause a… read more here.
Keywords: jcpyv infection; kinase; erk; infection ... See more keywords
CD8 T Cells and STAT1 Signaling Are Essential Codeterminants in Protection from Polyomavirus Encephalopathy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.02038-19
Abstract: A comprehensive understanding of JCPyV-induced PML pathogenesis is needed to define determinants that predispose patients to PML, a goal whose urgency is heightened by the lack of anti-JCPyV agents. A handicap to achieving this goal… read more here.
Keywords: mupyv; cd8 cells; jcpyv; infection ... See more keywords
Transient biopsy-proven progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS) in an elderly woman without known immunodeficiency: a case report
Sign Up to like & getrecommendations! Published in 2024 at "BMC Neurology"
DOI: 10.1186/s12883-024-03945-0
Abstract: Progressive multifocal leukoencephalopathy (PML) is a severe opportunistic brain disease caused by lytic JC polyomavirus (JCPyV) replication in oligodendrocytes. Although JCPyV infection is common in the general population, PML almost exclusively occurs in patients immunocompromised… read more here.
Keywords: immune reconstitution; jcpyv; pml; biopsy ... See more keywords
Alterations of the miR-126-3p/POU2AF1/Spi-B Axis and JCPyV Reactivation in Multiple Sclerosis Patients Receiving Natalizumab
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.819911
Abstract: Natalizumab (NTZ) can reactivate human polyomavirus John Cunningham polyomavirus (JCPyV) latent infection and lead to progressive multifocal leukoencephalopathy (PML). NTZ modulates the expression of microRNA-126-3p (miR-126-3p) and its target genes, Spi-B, POU2AF1, and vascular cell… read more here.
Keywords: spi pou2af1; multiple sclerosis; mir 126; jcpyv ... See more keywords
Human Polyomavirus JCPyV and Its Role in Progressive Multifocal Leukoencephalopathy and Oncogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.00711
Abstract: The human neurotropic virus JCPyV, a member of the Polyomaviridiae family, is the opportunistic infectious agent of Progressive Multifocal Leukoencephalopathy (PML), a fatal disease seen in severe immunosuppressive conditions and, during the last decade, in… read more here.
Keywords: progressive multifocal; multifocal leukoencephalopathy; role; jcpyv ... See more keywords
The oncogenic roles of JC polyomavirus in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.976577
Abstract: JC polyomavirus (JCPyV) belongs to the human polyomavirus family. Based on alternative splicing, the early region encodes the large and small T antigens, while the late region encodes the capsid structural proteins (VP1, VP2, and… read more here.
Keywords: dna; jcpyv; oncogenic roles; polyomavirus cancer ... See more keywords