JC Polyomavirus Infection Reveals Delayed Progression of the Infectious Cycle in Normal Human Astrocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.01331-19
Abstract: Animal models are crucial in advancing biomedical research and defining the pathogenesis of human disease. Unfortunately, not all diseases can be easily modeled in a nonhuman host or such models are cost prohibitive to generate,… read more here.
Keywords: jcpyv; infection; jcpyv infection; cell ... See more keywords
ERK Is a Critical Regulator of JC Polyomavirus Infection
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01529-17
Abstract: ABSTRACT The human JC polyomavirus (JCPyV) infects the majority of the population worldwide and presents as an asymptomatic, persistent infection in the kidneys. In individuals who are immunocompromised, JCPyV can become reactivated and cause a… read more here.
Keywords: jcpyv infection; kinase; erk; infection ... See more keywords
JCPyV miR-J1-5p in Urine of Natalizumab-Treated Multiple Sclerosis Patients
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13030468
Abstract: The use of Natalizumab in Multiple Sclerosis (MS) can cause the reactivation of the polyomavirus JC (JCPyV); this may result in the development of progressive multifocal leukoencephalopathy (PML), a rare and usually lethal disease. JCPyV… read more here.
Keywords: natalizumab treated; jcpyv infection; jcpyv mir; multiple sclerosis ... See more keywords
The MAPK/ERK Pathway and the Role of DUSP1 in JCPyV Infection of Primary Astrocytes
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13091834
Abstract: JC polyomavirus (JCPyV) is a neuroinvasive pathogen causing a fatal, demyelinating disease of the central nervous system (CNS) known as progressive multifocal leukoencephalopathy (PML). Within the CNS, JCPyV predominately targets two cell types: oligodendrocytes and… read more here.
Keywords: jcpyv infection; infection primary; infection; erk pathway ... See more keywords
Complexities of JC Polyomavirus Receptor-Dependent and -Independent Mechanisms of Infection
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14061130
Abstract: JC polyomavirus (JCPyV) is a small non-enveloped virus that establishes lifelong, persistent infection in most of the adult population. Immune-competent patients are generally asymptomatic, but immune-compromised and immune-suppressed patients are at risk for the neurodegenerative… read more here.
Keywords: jcpyv infection; complexities polyomavirus; infection; receptor dependent ... See more keywords