Correlation between anti‐JC‐virus and anti‐cytomegalovirus, ‐Epstein–Barr virus and ‐measles/‐rubella/‐varicella–zoster‐virus antibodies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Virology"
DOI: 10.1002/jmv.24590
Abstract: Anti‐JCV antibody status is used for PML‐risk‐stratification in MS patients before and during Natalizumab therapy. JCV antibodies can be detected in around 60% of MS patients, however, only a small proportion actually develop PML. As… read more here.
Keywords: measles rubella; jcv; rubella varicella; varicella zoster ... See more keywords
Viral replication centers and the DNA damage response in JC virus-infected cells.
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2018.12.014
Abstract: JCV is a human polyomavirus (PyV) that establishes a persistent infection in its host. Current immunomodulatory therapies, such as Natalizumab for multiple sclerosis, can result in JCV reactivation, leading to the debilitating brain disease progressive… read more here.
Keywords: dna damage; damage response; jcv; host ... See more keywords
Progressive multifocal leukoencephalopathy in a patient post allo-HCT successfully treated with JC virus specific donor lymphocytes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-020-02337-5
Abstract: Background Progressive multifocal leukoencephalopathy is a demyelinating CNS disorder. Reactivation of John Cunningham virus leads to oligodendrocyte infection with lysis and consequent axonal loss due to demyelination. Patients usually present with confusion and seizures. Late… read more here.
Keywords: allo hct; jcv; virus specific; cell ... See more keywords
The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF- kappaB activation
Sign Up to like & getrecommendations! Published in 2017 at "Virology Journal"
DOI: 10.1186/s12985-017-0707-7
Abstract: BackgroundInfection of glial cells by human neurotropic polyomavirus JC (JCV), the causative agent of the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), rapidly inflicts damage to cellular DNA. This activates DNA damage response (DDR) signaling… read more here.
Keywords: dna; infection; jcv infection; jcv ... See more keywords
Favipiravir treatment prolongs the survival in a lethal mouse model intracerebrally inoculated with Jamestown Canyon virus
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0009553
Abstract: Background Jamestown Canyon virus (JCV) is a mosquito-borne orthobunyavirus that causes acute febrile illness, meningitis, and meningoencephalitis, primarily in North American adults. Currently, there are no available vaccines or specific treatments against JCV infections. Methodology/Principal… read more here.
Keywords: jamestown canyon; treatment; infection; dpi ... See more keywords
Differences in neuroinvasion and protective innate immune pathways between encephalitic California Serogroup orthobunyaviruses
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010384
Abstract: The California serogroup (CSG) of Orthobunyaviruses comprises several members capable of causing neuroinvasive disease in humans, including La Crosse orthobunyavirus (LACV), Jamestown Canyon orthobunyavirus (JCV), and Inkoo orthobunyavirus (INKV). Despite being genetically and serologically closely… read more here.
Keywords: innate; ifn; jcv; mice ... See more keywords
The Oncogenic Roles of JC Virus T Antigen in Breast Carcinogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.687444
Abstract: Purpose: JC virus (JCV) infects 80–90% of the population and results in progressive multifocal leukoencephalopathy upon immunodeficiency. The study aimed to pathologically clarify the oncogenic roles of T antigen in human breast cancers. Methods: Breast… read more here.
Keywords: breast; oncogenic roles; breast cancer; jcv ... See more keywords
Outbreak Investigation: Jamestown Canyon Virus Surveillance in Field-Collected Mosquitoes (Diptera: Culicidae) From Wisconsin, USA, 2018–2019
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Public Health"
DOI: 10.3389/fpubh.2022.818204
Abstract: During the summers of 2017–2019, 60 human cases of Jamestown Canyon virus-associated disease were reported in the State of Wisconsin, U.S.A; by comparison, there were 28 cases in the 5 years prior. Jamestown Canyon virus… read more here.
Keywords: surveillance; jamestown canyon; transmission; canyon virus ... See more keywords
The Role of the JC Virus in Central Nervous System Tumorigenesis
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21176236
Abstract: Cancer is the second leading cause of mortality worldwide. The study of DNA tumor-inducing viruses and their oncoproteins as a causative agent in cancer initiation and tumor progression has greatly enhanced our understanding of cancer… read more here.
Keywords: tumorigenesis; nervous system; central nervous; jcv ... See more keywords