Autoantibodies in Juvenile Dermatomyositis: Need to Bridge the Bench and Bedside Gap
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DOI: 10.1007/s12098-021-03971-7
Abstract: Juvenile dermatomyositis (JDM) is an autoimmune disease, and is associated with various autoantibodies. These autoantibodies are classified as either myositis-specific antibodies (MSAs) or myositis-associated antibodies (MAAs). MSAs are exclusively detected in patients with idiopathic inflammatory… read more here.
Keywords: antibody; disease; study; cohort ... See more keywords
Clinical significance of subcutaneous fat and fascial involvement in juvenile dermatomyositis
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DOI: 10.1080/14397595.2018.1511026
Abstract: Abstract Objectives: Subcutaneous involvement, including calcinosis and panniculitis, is a more common complication in juvenile dermatomyositis (JDM) than in adult dermatomyositis. Magnetic resonance imaging (MRI) is useful for evaluating disease distribution. We investigated the clinical… read more here.
Keywords: subcutaneous fat; juvenile dermatomyositis; jdm; clinical significance ... See more keywords
Biologics in refractory idiopathic inflammatory myositis (IIM): What experience in juvenile vs adult myositis tells us about the use of biologics in pediatric IIM
Sign Up to like & getrecommendations! Published in 2021 at "Modern Rheumatology"
DOI: 10.1080/14397595.2021.1881027
Abstract: Abstract Juvenile dermatomyositis (JDM) is an extremely heterogeneous orphan disease with limited amount of dedicated research on the subject matter. Recent research suggests that JDM may not just be the classic antibody driven complements mediated… read more here.
Keywords: biologics refractory; refractory idiopathic; treatment; juvenile ... See more keywords
Genetic Analysis for Type 1 Diabetes Genes in Juvenile Dermatomyositis Unveils Genetic Disease Overlap.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac100
Abstract: OBJECTIVES Juvenile dermatomyositis (JDM) is a serious autoimmune and complex genetic disease. Another autoimmune genetic disease, type 1 diabetes (T1D), has been observed for significantly increased prevalence in families with JDM, while increased JDM risk… read more here.
Keywords: analysis; type diabetes; juvenile dermatomyositis; genetic disease ... See more keywords
Features distinguishing clinically amyopathic juvenile dermatomyositis from juvenile dermatomyositis
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DOI: 10.1093/rheumatology/key190
Abstract: Objective We examined features of clinically amyopathic JDM (CAJDM), in which patients have characteristic rashes with little to no evidence of muscle involvement, to determine whether this is a distinct phenotype from JDM. Methods Demographic,… read more here.
Keywords: jdm; juvenile dermatomyositis; cajdm patients; cajdm ... See more keywords
G448 Juvenile dermatomyositis associated with interstitial lung disease: would anti-mda5 antibody detection improve early diagnosis and management?
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2018-rcpch.437
Abstract: Aims We describe a case of anti-MDA5 antibody positive Juvenile Dermatomyositis(JDM) associated with interstitial lung disease(ILD) and propose early antibody detection may guide management and improve outcome. Methods A 15-year-old male presented with a 3 month… read more here.
Keywords: anti mda5; jdm; antibody; lung disease ... See more keywords
Adipokine profile in long-term juvenile dermatomyositis, and associations with adipose tissue distribution and cardiac function: a cross-sectional study
Sign Up to like & getrecommendations! Published in 2023 at "RMD Open"
DOI: 10.1136/rmdopen-2022-002815
Abstract: Objectives In long-term juvenile dermatomyositis (JDM), altered adipose tissue distribution and subclinical cardiac dysfunction have been described. Our aims were to compare adipokine levels in patients with JDM after long-term disease with controls, and explore… read more here.
Keywords: long term; jdm active; adipose tissue; jdm ... See more keywords
Seasonality and geography of diabetes mellitus in United States of America dogs
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DOI: 10.1371/journal.pone.0272297
Abstract: The diagnosis of type 1 diabetes mellitus (DM) in humans is associated with high altitude, few sunshine hours, cold climate, and winter. The goals of this study were to investigate seasonal and geographic patterns of… read more here.
Keywords: breed; geography; jdm; diabetes mellitus ... See more keywords
Single-cell profiling of peripheral blood and muscle cells reveals inflammatory features of juvenile dermatomyositis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1166017
Abstract: Introduction: Juvenile dermatomyositis (JDM) is a rare yet serious childhood systemic autoimmune condition that primarily causes skin rashes and inflammatory myopathy of the proximal muscles. Although the associated immune response involves the innate and adaptive… read more here.
Keywords: cell; muscle; blood muscle; jdm ... See more keywords
Clues to Disease Activity in Juvenile Dermatomyositis: Neopterin and Other Biomarkers
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DOI: 10.3390/diagnostics12010008
Abstract: Easily accessible biomarkers are urgently needed to evaluate immune activation in Juvenile Dermatomyositis (JDM). The goal of this retrospective study is to define immunological and clinical differences between untreated JDM patients with either normal or… read more here.
Keywords: disease activity; juvenile dermatomyositis; jdm; activity ... See more keywords