Laminin 332-Dependent YAP Dysregulation Depletes Epidermal Stem Cells in Junctional Epidermolysis Bullosa.
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DOI: 10.1016/j.celrep.2019.04.055
Abstract: Laminin 332-deficient junctional epidermolysis bullosa (JEB) is a severe genetic skin disease. JEB is marked by epidermal stem cell depletion, the origin of which is unknown. We show that dysregulation of the YAP and TAZ… read more here.
Keywords: stem cells; jeb; yap; epidermal stem ... See more keywords
O19 Improvement of a junctional epidermolysis bullosa mouse model
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DOI: 10.1093/bjd/ljae105.019
Abstract: Junctional epidermolysis bullosa (JEB) is the most severe of the epidermolysis bullosa (EB) disorders and is caused by mutations in genes encoding the skin basement membrane proteins laminin 332, type XVII collagen or integrin α6β4.… read more here.
Keywords: jeb; mouse model; epidermolysis bullosa; model ... See more keywords
P16 Fibroblast signalling crosstalk drives junctional epidermolysis bullosa disease progression
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DOI: 10.1093/bjd/ljae105.038
Abstract: Junctional epidermolysis bullosa (JEB) is a devastating hereditary skin disorder characterized by severe fragility of skin and mucus membrane, emerges as blistering with little or no trauma. The major classification of JEB includes JEB intermediate… read more here.
Keywords: jeb; disease; epidermolysis bullosa; fibroblast ... See more keywords