Resveratrol ameliorates toxic effects of cadmium on placental development in mouse placenta and human trophoblast cells.
Sign Up to like & getrecommendations! Published in 2021 at "Birth defects research"
DOI: 10.1002/bdr2.1962
Abstract: BACKGROUND Cadmium (Cd) is a common heavy metal pollutant. Prenatal exposure to Cd results in adverse effects on fetal development. Placental apoptosis, inflammation, and epigenetic disruption have been implicated in Cd-induced placental toxicity. Resveratrol (Res)… read more here.
Keywords: resveratrol ameliorates; placental toxicity; placenta; expression ... See more keywords
Long noncoding RNA H19 promotes chemotherapy resistance in choriocarcinoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28775
Abstract: Choriocarcinoma (CC) is a trophoblast tumor prone to early distant organ metastases. At present, the main treatment for CC is chemotherapy, but chemotherapy resistance readily occurs and leads to treatment failure. H19 is a long… read more here.
Keywords: jeg mtx; resistance; jeg cells; jeg ... See more keywords
Alteration of Placental Deiodinase 3 Expression by BDE 209 and Possible Protection by Taurine in Human Placenta-Derived JEG Cells Under Hypoxia.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8023-5_67
Abstract: Thyroid hormones are key hormones involved in growth and development. Changes in their levels can cause embryonic brain developmental damage in the first trimester. Studies have shown that polybrominated diphenyl ethers (PBDEs) have developmental neurotoxicity… read more here.
Keywords: derived jeg; human placenta; jeg cells; placenta derived ... See more keywords
MicroRNA-126 suppresses the invasion of trophoblast-model JEG-3 cells by targeting LIN28A.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.01.077
Abstract: Inadequate trophoblast invasion and impaired trophoblast-induced vascular remodeling are features of preeclampsia. In this context, an angiogenesis-related microRNA, miR-126, is abnormally expressed in preeclampsia placentas, but its role in trophoblast development remains unclear. The purpose… read more here.
Keywords: 126 suppresses; mir 126; invasion; jeg ... See more keywords
Triphenyl phosphate disturbs the lipidome and induces endoplasmic reticulum stress and apoptosis in JEG-3 cells.
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2021.129978
Abstract: Triphenyl phosphate (TPP) is a frequently used aryl organophosphate flame retardant. Epidemiological studies have shown that TPP and its metabolite diphenyl phosphate (DPP) can accumulate in the placenta, and positively correlated with abnormal birth outcomes.… read more here.
Keywords: endoplasmic reticulum; reticulum stress; jeg cells; triphenyl phosphate ... See more keywords
NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells.
Sign Up to like & getrecommendations! Published in 2021 at "Immunobiology"
DOI: 10.1016/j.imbio.2021.152125
Abstract: NK cell development is affected by their cellular microenvironment and cytokines, including IL-15 and IL-18. NK cells can differentiate in secondary lymphoid organs, liver and within the uterus in close contact with trophoblast cells. The… read more here.
Keywords: cell; presence; trophoblast cells; function ... See more keywords
Placental homing peptide guides HIF1α‑silenced exosomes conjugates for targeted enhancement of invasion of trophoblast cells.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular medicine reports"
DOI: 10.3892/mmr.2023.13022
Abstract: There is a current lack of availability of therapeutics to treat Preeclampsia (PE), primarily due to the risk of harm to the fetus. Hypoxia‑inducible factor‑1α (HIF1α) is highly expressed in trophoblast cells and suppresses their… read more here.
Keywords: hif1; silenced exosomes; hif1 silenced; invasion ... See more keywords