Abstract A079: Glutamine antagonist prodrug JHU083 reprograms immunosuppressive tumor-associated macrophages to drive tumor immunity in urologic cancers
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DOI: 10.1158/1538-7445.prca2023-a079
Abstract: Tumor metabolism is emerging as a regulator of immune mediated anti-tumor responses. Previously, we reported increased immunosuppressive tumor-associated macrophages (TAMs) infiltration with disease progression in prostate adenocarcinoma (PCa).1 Glutamine metabolism has been implicated in metastatic… read more here.
Keywords: anti tumor; immunosuppressive tumor; jhu083; tumor ... See more keywords