Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer’s Disease
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DOI: 10.2147/dddt.s357061
Abstract: Background Abnormal sphingolipid metabolism is closely related to the occurrence and development of Alzheimer’s disease (AD). With heat-clearing and detoxifying effects, Huanglian Jiedu decoction (HLJDD) has been used to treat dementia and improve learning and… read more here.
Keywords: metabolism; sphingolipid metabolism; alzheimer disease; jiedu decoction ... See more keywords
Huashi Jiedu Decoction Enhances 5-Fluorouracil Efficacy in Gastric Cancer via miRNA-21-3p/p53 Pathway
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DOI: 10.2147/dddt.s513371
Abstract: Purpose To explore the mechanism of Huashi Jiedu Decoction (HJD) synergizing with 5-fluorouracil (5-Fu) in gastric cancer (GC) therapy. Methods MicroRNAs (miRNAs) and genes involved in HJD-mediated GC treatment were identified using ultra-high-performance liquid chromatography… read more here.
Keywords: p53 pathway; jiedu decoction; mirna p53; gastric cancer ... See more keywords
A Novel Strategy for Decoding and Validating the Combination Principles of Huanglian Jiedu Decoction From Multi-Scale Perspective
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DOI: 10.3389/fphar.2020.567088
Abstract: Traditional Chinese medicine (TCM) formulas treat complex diseases through combined botanical drugs which follow specific compatibility rules to reduce toxicity and increase efficiency. “Jun, Chen, Zuo and Shi” is one of most used compatibility rules… read more here.
Keywords: zuo shi; jiedu decoction; huanglian jiedu; chen zuo ... See more keywords
The interaction of MD-2 with small molecules in huanglian jiedu decoction play a critical role in the treatment of sepsis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.947095
Abstract: Huanglian Jiedu Decoction (HJD) is used for treating sepsis in China. Active components from HJD refer to various active ingredients of HJD, while active component formulation (ACF) refers to the combination of palmatine, berberine, baicalin,… read more here.
Keywords: sepsis; jiedu decoction; hjd; huanglian jiedu ... See more keywords