Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52537-3
Abstract: JIP3 and JIP4 (JNK-interacting proteins 3 and 4) are adaptors for cargo recruitment by dynein/dynactin and kinesin1 motors. Both are dimers that are stabilised by two sections of leucine zipper coiled coils. The N-terminal Leucine… read more here.
Keywords: lzi tandem; rh1 lzi; rh1; jip3 ... See more keywords
Doublecortin and JIP3 are neural-specific counteracting regulators of dynein-mediated retrograde trafficking
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DOI: 10.1101/2022.08.10.503449
Abstract: Mutations in the microtubule (MT)-binding protein doublecortin (DCX) or in the MT- based molecular motor dynein result in lissencephaly. However, a functional link between DCX and dynein has not been defined. Here, we demonstrate that… read more here.
Keywords: doublecortin; dcx; jip3; dynein mediated ... See more keywords