Apparent Absence of Selective Pressure on Pneumocystis jirovecii Organisms in Patients with Prior Methotrexate Exposure
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DOI: 10.1128/aac.00990-22
Abstract: Pneumocystis jirovecii infections occur in patients treated with methotrexate (MTX) because of immunosuppressive effects of this highly potent dihydrofolate reductase (DHFR) inhibitor. Conversely, MTX may act as an anti-P. jirovecii drug and consequently may exert… read more here.
Keywords: jirovecii; jirovecii organisms; pneumocystis jirovecii; selective pressure ... See more keywords