Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling
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DOI: 10.1038/s41388-021-02173-x
Abstract: Programmed death-ligand 1 (PD-L1) is an important immunosuppressive molecule highly expressed on the surface of cancer cells. IFNγ triggered cancer cell immunosuppression against CD8+ T cell surveillance via up-regulation of PD-L1. Histone demethylase JMJD2D promotes… read more here.
Keywords: cancer; tumor; jmjd2d; stat3 irf1 ... See more keywords
Histone Lysine Demethylase JMJD2D/KDM4D and Family Members Mediate Effects of Chronic Social Defeat Stress on Mouse Hippocampal Neurogenesis and Mood Disorders
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DOI: 10.3390/brainsci10110833
Abstract: Depression, anxiety and related mood disorders are major psychiatric illnesses worldwide, and chronic stress appears to be one of the primary underlying causes. Therapeutics to treat these debilitating disorders without a relapse are limited due… read more here.
Keywords: histone lysine; jmjd2d; neurogenesis; mood disorders ... See more keywords
Histone Demethylase JMJD2D: A Novel Player in Colorectal and Hepatocellular Cancers
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DOI: 10.3390/cancers14122841
Abstract: Simple Summary Histone demethylase JMJD2D is a multifunctional epigenetic factor coordinating androgen receptor activation, DNA damage repair, DNA replication, cell cycle regulation, and inflammation modulation. JMJD2D is also a well-established epigenetic facilitator in the progression… read more here.
Keywords: jmjd2d; progression; histone demethylase; demethylase jmjd2d ... See more keywords