Palmitate‐TLR4 signaling regulates the histone demethylase, JMJD3, in macrophages and impairs diabetic wound healing
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048651
Abstract: Chronic macrophage inflammation is a hallmark of type 2 diabetes (T2D) and linked to the development of secondary diabetic complications. T2D is characterized by excess concentrations of saturated fatty acids (SFA) that activate innate immune… read more here.
Keywords: jmjd3; histone demethylase; palmitate; inflammation ... See more keywords
Silencing ATF4 inhibits JMJD3-dependent JUNB/ETS1 axis and mitigates cerebral ischemic injury.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23070
Abstract: Activating transcription factor 4 (ATF4) is known to play an important role in cerebral ischemia through apoptosis and neuron regulation. Histone demethylase JMJD3, specifically removing the methylation of H3K27me3, is highlighted to attenuate cerebral ischemic… read more here.
Keywords: expression; jmjd3; atf4; ischemic injury ... See more keywords
JMJD3 downregulates IL4i1 aggravating lipopolysaccharide‐induced acute lung injury via H3K27 and H3K4 demethylation
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23725
Abstract: The pro‐inflammation M1 to anti‐inflammation M2 macrophage ratio contribute to the severity of lipopolysaccharide (LPS)‐induced acute lung injury (ALI). JMJD3 aggravates the inflammatory reaction through affecting epigenetic modification and macrophage's phenotype to deteriorate ALI. To… read more here.
Keywords: macrophage ratio; demethylation; jmjd3; induced acute ... See more keywords
Jumonji domain containing-3 (JMJD3) inhibition attenuates IL-1β-induced chondrocytes damage in vitro and protects osteoarthritis cartilage in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation Research"
DOI: 10.1007/s00011-020-01356-8
Abstract: Objectives This study aimed to explore the effects and relative mechanism of JMJD3 on knee osteoarthritis (OA). Methods In this study, we first analyzed the expression of JMJD3 in OA cartilage using western blot and… read more here.
Keywords: jmjd3; group; damage; vitro ... See more keywords
JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML
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DOI: 10.1038/s41467-018-05548-z
Abstract: JMJD3, a stress-inducible H3K27 demethylase, plays a critical regulatory role in the initiation and progression of malignant hematopoiesis. However, how this histone modifier affects in a cell type-dependent manner remains unclear. Here, we show that… read more here.
Keywords: jmjd3; oncorepressor; jmjd3 facilitates; ebp centered ... See more keywords
JMJD3 Promotes Myeloid Fibroblast Activation and Macrophage Polarization in Kidney Fibrosis.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16096
Abstract: BACKGROUND AND PURPOSE Renal fibrosis is a common feature of chronic kidney disease. Myeloid fibroblasts and macrophages contribute significantly to the pathogenesis of renal fibrosis. However, the molecular mechanisms underlying myeloid fibroblast activation and macrophage… read more here.
Keywords: macrophage polarization; fibrosis; myeloid fibroblast; jmjd3 ... See more keywords
JMJD3 activated hyaluronan synthesis drives muscle regeneration in an inflammatory environment
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abm9735
Abstract: Muscle stem cells (MuSCs) reside in a specialized niche that ensures their regenerative capacity. Although we know that innate immune cells infiltrate the niche in response to injury, it remains unclear how MuSCs adapt to… read more here.
Keywords: jmjd3; muscle; muscle stem; stem cells ... See more keywords
Jumonji domain-containing protein-3 (JMJD3/Kdm6b) is critical for normal ovarian function and female fertility.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac047
Abstract: In females, reproductive success is dependent on the expression of a number of genes regulated at different levels, one of which is through epigenetic modulation. How a specific epigenetic modification regulates gene expression and their… read more here.
Keywords: ovarian function; jmjd3; female fertility; expression ... See more keywords
JMJD3 suppresses stem cell-like characteristics in breast cancer cells by downregulation of Oct4 independently of its demethylase activity
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15747
Abstract: Epigenetic regulator JMJD3 plays an important role in both tumor progression and somatic cell reprogramming. Here, we explored the effect of JMJD3 on the stem cell-like characteristics of breast cancer and its underlying mechanism involving… read more here.
Keywords: cell like; jmjd3; breast cancer; stem cell ... See more keywords
Inhibitor of H3K27 demethylase JMJD3/UTX GSK-J4 is a potential therapeutic option for castration resistant prostate cancer
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DOI: 10.18632/oncotarget.19100
Abstract: Androgen receptor (AR) mediates initiation and progression of prostate cancer (PCa); AR-driven transcription is activated by binding of androgens to the ligand-binding domain (LBD) of AR. Androgen ablation therapy offers only a temporary relief of… read more here.
Keywords: jmjd3; jmjd3 utx; prostate cancer; castration resistant ... See more keywords
The pharmacological role of histone demethylase JMJD3 inhibitor GSK-J4 on glioma cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19793
Abstract: Glioma is regarded as the most prevalent malignant carcinoma of the central nervous system, and lack of effective treatment. Thus, the development of new therapeutic strategies targeting glioma is of significant clinical importance. In the… read more here.
Keywords: jmjd3; inhibitor gsk; glioma; treatment ... See more keywords