The JMJD6/HURP axis promotes cell migration via NF‐κB‐dependent centrosome repositioning and Cdc42‐mediated Golgi repositioning
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30900
Abstract: Golgi apparatus (GA) and centrosome reposition toward cell leading end during directional cell migration in a coupling way, thereby determining cell polarity by transporting essential factors to the proximal plasma membrane. The study provides mechanistic… read more here.
Keywords: jmjd6; hurp; cdc42; migration ... See more keywords
Jumonji: Welcome to the World of Interferon Signaling in Alcohol and HCV
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2017.11.009
Abstract: lcoholic liver disease and hepatitis C virus (HCV) Ainfection, either alone or in combination, affect 2 out of 3 persons living with chronic liver disease in the Western world. Alcohol consumption not only increases the… read more here.
Keywords: jmjd6; gastroenterology; hcv; interferon ... See more keywords
In Silico Discovery of JMJD6 Inhibitors for Cancer Treatment.
Sign Up to like & getrecommendations! Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00264
Abstract: The 2-oxoglutarate (2OG)-dependent oxygenase JMJD6 is emerging as a potential anticancer target, but its inhibitors have not been reported so far. In this study, we reported an in silico protocol to discover JMJD6 inhibitors targeting… read more here.
Keywords: jmjd6; jmjd6 inhibitors; discovery jmjd6; silico discovery ... See more keywords
Patient-derived xenografts (PDX) identify JMJD6 inhibitor as an effective therapeutic medicine in colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz246.109
Abstract: Abstract Background The Jmjc-domain-containing protein 6 (JMJD6) is a member of JmjC oxygenases that contain both arginine demethylase and lysine hydroxylase activities. Overexpression of JMJD6 has been reported to be associated with the development of… read more here.
Keywords: medicine; jmjd6 inhibitor; colorectal cancer; jmjd6 ... See more keywords
JMJD6 Shapes a Pro-tumor Microenvironment via ANXA1-Dependent Macrophage Polarization in Breast Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-22-0370
Abstract: Abstract Breast cancer is the most common type of cancer in women worldwide, with the luminal subtype being the most widespread. Although characterized by better prognosis compared with other subtypes, luminal breast cancer is still… read more here.
Keywords: jmjd6; microenvironment; breast cancer; tumor ... See more keywords
JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer"
DOI: 10.1186/s12943-017-0744-2
Abstract: BackgroundMelanoma, originated from melanocytes located on the basal membrane of the epithelial tissue, is the most aggressive form of skin cancer that accounts for 75% of skin cancer-related death. Although it is believed that BRAF… read more here.
Keywords: melanoma; mapk signaling; melanoma carcinogenesis; jmjd6 ... See more keywords
Fibronectin and JMJD6 Signature in Circulating Placental Extracellular Vesicles for the Detection of Preeclampsia
Sign Up to like & getrecommendations! Published in 2023 at "Endocrinology"
DOI: 10.1210/endocr/bqad013
Abstract: Abstract Preeclampsia (PE) is a major obstetric complication that is challenging to predict. Currently, there are limited tools to assess placental health/function in crucial gestational periods for diagnosis and early prediction. The glycoprotein fibronectin (FN)… read more here.
Keywords: circulating placental; fibronectin; jmjd6; extracellular vesicles ... See more keywords
JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009366
Abstract: The negative regulation of antiviral immune responses is essential for the host to maintain homeostasis. Jumonji domain-containing protein 6 (JMJD6) was previously identified with a number of functions during RNA virus infection. Upon viral RNA… read more here.
Keywords: jmjd6; irf3 k48; rna; antiviral signaling ... See more keywords
Elucidating the role of PRMTs in prostate cancer using open access databases and a patient cohort dataset.
Sign Up to like & getrecommendations! Published in 2022 at "Histology and histopathology"
DOI: 10.14670/hh-18-513
Abstract: Protein arginine methylation is an understudied epigenetic mechanism catalyzed by enzymes known as Protein Methyltransferases of Arginine (PRMTs), while the opposite reaction is performed by Jumonji domain- containing protein 6 (JMJD6). There is increasing evidence… read more here.
Keywords: prostate cancer; jmjd6; prmts; expression ... See more keywords
Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00675
Abstract: Ras genes are among the most commonly mutated genes in human cancer; yet our understanding of their oncogenic activity at the molecular mechanistic level is incomplete. To identify downstream events that mediate ras-induced cellular transformation… read more here.
Keywords: melanoma; jmjd6; mir 146a; ras induced ... See more keywords
Jumonji domain-containing protein 6 functions as a marker of head and neck squamous cell carcinoma at advanced stage with no effect on prognosis
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Letters"
DOI: 10.3892/ol.2019.10938
Abstract: A number of studies have reported the upregulation and functional roles of Jumonji domain-containing protein 6 (JMJD6) in various types of cancer. However, little is known regarding the clinical significance of JMJD6 in head and… read more here.
Keywords: domain containing; cell; jmjd6; jumonji domain ... See more keywords