Disease Risk Index Predicts Relapse in Children Undergoing Allogeneic Hematopoietic Cell Transplantation (HCT)
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.384
Abstract: Relapse is most common cause of death after HCT. However, given the heterogeneity of diseases and disease states among patients (pts), risk for relapse is often difficult to manage in clinical trials when survival is… read more here.
Keywords: dri; risk; relapse; jmml ... See more keywords
Noonan syndrome‐associated myeloproliferative disorder with somatically acquired monosomy 7: impact on clinical decision making
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DOI: 10.1111/bjh.16191
Abstract: Haematological manifestations in Noonan syndrome (NS), the most common RASopathy, encompass a broad phenotypic spectrum ranging from transient monocytosis, thrombocytopenia to myeloproliferative disorder (MPD) (Roberts et al, 2013). In the majority of patients, NS-MPD is… read more here.
Keywords: methylation; somatically acquired; noonan syndrome; jmml ... See more keywords
CMML/JMML PDXs: as easy as 1, 2, NSG-SGM3.
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DOI: 10.1182/blood-2017-06-789123
Abstract: In this issue of Blood , Yoshimi et al describe a simple method to establish patient-derived xenografts (PDXs) of chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) with remarkable efficiency. These morphologically, immunophenotypically, and… read more here.
Keywords: pdxs easy; jmml; jmml pdxs; cmml jmml ... See more keywords
DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia: An International Collaborative Analysis and Development of a Common Diagnostic Platform
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DOI: 10.1182/blood-2018-99-114918
Abstract: Juvenile myelomonocytic leukemia (JMML) is a rare myeloproliferative neoplasm of early childhood characterized by Ras pathway mutations and aberrant DNA methylation. Despite allogeneic hematopoietic stem cell transplantation (HSCT) approx. 30% of patients (pts) succumb to… read more here.
Keywords: methylation; jmml; analysis; cohort ... See more keywords
Genetic Alterations Precede DNA Methylation Changes in Juvenile Myelomonocytic Leukemia
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DOI: 10.1182/blood-2020-143443
Abstract: Introduction Juvenile myelomonocytic leukemia (JMML) is a rare and highly aggressive myeloid malignancy of early childhood. Approximately 95% of patients have at least one mutation that leads to hyperactive RAS signaling. Both the presence of… read more here.
Keywords: methylation; diagnosis; jmml; methylation profiling ... See more keywords
Molecular and Functional Characterization of Disease-Propagating Stem Cells in Juvenile Myelomonocytic Leukemia
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DOI: 10.1182/blood.v130.suppl_1.379.379
Abstract: Juvenile Myelomonocytic Leukemia (JMML) is a rare, poor prognosis childhood leukemia characterized by aberrant proliferation of dysplastic myeloid cells and germline or somatic RAS-activating mutations. The only curative treatment is hematopoietic stem cell (HSC) transplantation,… read more here.
Keywords: hsc; jmml; disease; leukemia ... See more keywords
Long-term proliferation of immature hypoxia-dependent JMML cells supported by a 3D in vitro system
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DOI: 10.1182/bloodadvances.2021006746
Abstract: Key Points • A defined 3D in vitro model, under hypoxic condition, sustains long-term propagation of JMML cells with specific hallmarks.• In vitro low oxygen levels drive a metabolic switch that redirect JMML cells toward… read more here.
Keywords: long term; term proliferation; proliferation immature; jmml ... See more keywords