The HIF1α/JMY pathway promotes glioblastoma stem-like cell invasiveness after irradiation
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DOI: 10.1038/s41598-020-75300-5
Abstract: Human glioblastoma (GBM) is the most common primary malignant brain tumor. A minor subpopulation of cancer cells, known as glioma stem-like cells (GSCs), are thought to play a major role in tumor relapse due to… read more here.
Keywords: stem like; jmy; hif1; stem ... See more keywords
JMY powers dendritogenesis and is regulated by CaM revealing a general, critical principle in neuromorphogenesis
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DOI: 10.1038/s42003-025-08208-3
Abstract: Local calcium signals and formation of actin filaments help to steer and power neuronal morphology development and plasticity. Yet, responsible actin nucleators and their linkage to calcium transients largely remained elusive. Here, we identify the… read more here.
Keywords: wh2 domain; principle; jmy; actin ... See more keywords
The p53 and Calcium Regulated Actin Rearrangement in Model Cells
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DOI: 10.3390/ijms23169078
Abstract: Long-term cellular stress maintains high intracellular Ca2+ concentrations which ultimately initiates apoptosis. Our interest is focused on how the gelsolin (GSN) and junctional mediating and regulating Y protein (JMY) play important roles in stress response.… read more here.
Keywords: calcium regulated; p53 calcium; regulated actin; p53 ... See more keywords