JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.
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DOI: 10.1021/acs.jmedchem.1c00935
Abstract: The discovery of a novel 2-aminotetrahydropyridine class of BACE1 inhibitors is described. Their pKa and lipophilicity were modulated by a pending sulfonyl group, while good permeability and brain penetration were achieved via intramolecular hydrogen bonding.… read more here.
Keywords: bace1 inhibitor; selective bace1; jnj 67569762; discovery ... See more keywords