An anticoagulant that does not cause bleeding – an abrupt stop on the road to the Holy Grail
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14638
Abstract: Cardiovascular diseases are major contributors to morbidity and mortality and pose a huge burden to the health care system. Thrombosis is the most common etiology for ischemic heart disease, ischemic stroke, and venous thromboembolism.1 Over… read more here.
Keywords: antibody; anticoagulant; time; venous thromboembolism ... See more keywords
JNJ-64179375 Inhibits Exosite I-Mediated Thrombin Activity While Preserving Exosite II and Active Site Function in Vitro
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-116291
Abstract: Anticoagulation requires a careful balance to achieve antithrombotic efficacy without disrupting normal hemostasis. Although current generation direct oral anticoagulants (DOACs) offer advantages over traditional warfarin or heparin therapy they still carry a bleeding risk, highlighting… read more here.
Keywords: exosite mediated; jnj; activity; active site ... See more keywords