Estrogen inhibits starvation‐induced apoptosis in osteocytes by a redox‐independent process involving association of JNK and glutathione S‐transferase P1‐1
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DOI: 10.1002/2211-5463.12216
Abstract: Estrogen deficiency causes bone loss as a result of microdamage, oxidative stress, and osteocyte apoptosis. A relationship between oxidative stress‐induced apoptosis, c‐Jun N‐terminal kinase (JNK) activation, and expression of factors involved in bone remodeling has… read more here.
Keywords: starvation induced; apoptosis; jnk; induced apoptosis ... See more keywords
Paclitaxel induces apoptosis through the TAK1–JNK activation pathway
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DOI: 10.1002/2211-5463.12917
Abstract: Paclitaxel (PTX) has previously been used to treat tumours of various tissue origins, such as lung, breast, ovarian, prostate cancers and leukemia. PTX‐induced apoptosis is associated with p38 mitogen‐activated protein kinase (p38 MAPK), extracellular signal‐regulated… read more here.
Keywords: apoptosis; jnk; cleavage; tak1 ... See more keywords
JNK‐IN‐8 treatment improves ARDS‐induced cognitive impairment by inhibiting JNK/NF‐κB‐mediated NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2980
Abstract: Cognitive impairment is a critical complication of acute respiratory distress syndrome (ARDS). However, effective interventions are lacking. Growing evidence demonstrates that c‐Jun N‐terminal kinase (JNK)‐mediated neuroinflammation is involved in the development of ARDS. Therefore, we… read more here.
Keywords: jnk mediated; induced cognitive; cognitive impairment; jnk ... See more keywords
RASSF1A inhibits epithelial–mesenchymal transition of gastric cancer cells by downregulating P‐JNK
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DOI: 10.1002/cbin.11958
Abstract: Gastric cancer (GC) is one of the most common gastrointestinal tumors. In this study, we assessed the biological role of Ras association domain family 1 isoform A (RASSF1A) in GC cells. Expressions of RASSF1A and… read more here.
Keywords: rassf1a; expression; jnk; gastric cancer ... See more keywords
Does JNK Regulate Acetaminophen Hepatotoxicity by Modulating Nrf2-dependent Genes or Mitochondrial Oxidant Stress?
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DOI: 10.1002/hep.31442
Abstract: We read with interest the recent paper by Chen and coworkers who provided evidence for Nrf2 as a novel target for c-jun N-terminal kinase (JNK).1 Although we agree that JNK activation is a critical part… read more here.
Keywords: nrf2 dependent; jnk; regulate acetaminophen; hepatotoxicity ... See more keywords
Phosphorylation and Stabilization of PIN1 by JNK Promote Intrahepatic Cholangiocarcinoma Growth
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DOI: 10.1002/hep.31983
Abstract: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive type of liver cancer in urgent need of treatment options. Aberrant activation of the c‐Jun N‐terminal kinase (JNK) pathway is a key feature in ICC and an attractive… read more here.
Keywords: phosphorylation stabilization; jnk; intrahepatic cholangiocarcinoma; stabilization pin1 ... See more keywords
The deleterious effect of stress‐induced depression on rat liver: Protective role of resveratrol and dimethyl fumarate via inhibiting the MAPK/ERK/JNK pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22627
Abstract: This study aimed to uncover the protective potentiality of resveratrol and dimethyl fumarate (DMF) in the liver of a chronic unpredictable mild stress (CUMS)‐induced depression animal model. Resveratrol and DMF significantly alleviated CUMS‐induced behavioral abnormalities… read more here.
Keywords: resveratrol; jnk; effect; resveratrol dimethyl ... See more keywords
ω‐hydroxyundec‐9‐enoic acid induces apoptosis by ROS mediated JNK and p38 phosphorylation in breast cancer cell lines
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DOI: 10.1002/jcb.26267
Abstract: ω‐Hydroxyundec‐9‐enoic acid (ω‐HUA), a plant secondary metabolite, exhibits anti‐fungal activity. However, its effect on breast cancer cells is unknown. Here, we investigated the anti‐ breast cancer activity of ω‐HUA and its underlying mechanism. Treatment of… read more here.
Keywords: cancer; jnk; cancer cell; breast cancer ... See more keywords
MicroRNA‐30d preserves pancreatic islet β‐cell function through negative regulation of the JNK signaling pathway via SOCS3 in mice with streptozotocin‐induced diabetes mellitus
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26569
Abstract: The loss of pancreatic islet β‐cell function represents the classical feature in the pathogenesis of type 2 diabetes mellitus (T2DM). Previous evidence has highlighted the involvement of the activated JNK pathway in relation to islet… read more here.
Keywords: streptozotocin induced; jnk; islet; mir 30d ... See more keywords
Suppression of Tafazzin promotes thyroid cancer apoptosis via activating the JNK signaling pathway and enhancing INF2‐mediated mitochondrial fission
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DOI: 10.1002/jcp.28287
Abstract: Tafazzin has been found to be associated with tumor progression. Mitochondrial homeostasis regulates cancer cell viability and metastasis. However, the roles of Tafazzin and mitochondrial homeostasis in thyroid cancer have not been explored. The aim… read more here.
Keywords: jnk; apoptosis; thyroid cancer; mitochondrial fission ... See more keywords
Reviving human γδT cells from apoptosis induced by IL‐12/18 via p‐JNK inhibition
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DOI: 10.1002/jlb.5ma0622-741r
Abstract: γδT cells recognize and exert cytotoxicity against tumor cells independently of MHC restriction and have antigen presentation and regulatory functions to promote adaptive immune responses. They are considered as potential immune cells for cellular immunotherapy… read more here.
Keywords: reviving human; apoptosis; human cells; cells apoptosis ... See more keywords