Spinal astrocytic c‐Jun N‐terminal kinase (JNK) activation as counteracting mechanism to the amitriptyline analgesic efficacy in painful peripheral neuropathies
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.01.025
Abstract: ABSTRACT Several drugs and agents are currently used for the treatment of neuropathic pain. Among them amitriptyline, a tricyclic antidepressant drug, represent a first line treatment. Despite its well‐documented clinical efficacy, amitriptyline is ineffective in… read more here.
Keywords: jnk activation; jnk; activation counteracting; efficacy ... See more keywords
Cabozantinib promotes erythroid differentiation in K562 erythroleukemia cells through global changes in gene expression and JNK activation.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer gene therapy"
DOI: 10.1038/s41417-021-00358-w
Abstract: Cabozantinib is a potent tyrosine kinase inhibitor with multiple targets including MET, VEGFR2, RET, KIT, and FLT3. Cabozantinib is widely used for the treatment of medullary thyroid cancer and renal cell carcinoma. We recently suggested… read more here.
Keywords: erythroid differentiation; jnk activation; differentiation; cabozantinib ... See more keywords
Mcl-1 expression and JNK activation induces a threshold for apoptosis in Bcl-xL-overexpressing hematopoietic cells
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DOI: 10.18632/oncotarget.14223
Abstract: The regulation of Mcl-1 expression is necessary for the induction of cancer cell apoptosis by ABTs such as ABT-737, ABT-263 and ABT-199. However, the reduction in Mcl-1 expression is not sufficient for initiating cell death… read more here.
Keywords: abt 199; apoptosis; mcl expression; jnk activation ... See more keywords
Mechanism and Therapeutic Targets of c-Jun-N-Terminal Kinases Activation in Nonalcoholic Fatty Liver Disease
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DOI: 10.3390/biomedicines10082035
Abstract: Non-alcoholic fatty liver (NAFL) is the most common chronic liver disease. Activation of mitogen-activated kinases (MAPK) cascade, which leads to c-Jun N-terminal kinase (JNK) activation occurs in the liver in response to the nutritional and… read more here.
Keywords: fatty liver; jun terminal; jnk activation; liver disease ... See more keywords