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   Articles with "jnk erk" as a keyword



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Midazolam prevents motor neuronal death from oxidative stress attack mediated by JNK-ERK pathway

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recommendations! Published in 2017 at "Human Cell"

DOI: 10.1007/s13577-017-0184-8

Abstract: Midazolam is a sedative used by patients with mechanical ventilation. However, the potential clinical value is not fully explored. In this report, we made use of a neuroblastoma-spinal cord hybrid motor neuron-like cell line NSC34,… read more here.

Keywords: oxidative stress; jnk erk; midazolam; jnk ... See more keywords
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Respective roles of the mitogen-activated protein kinase (MAPK) family members in pancreatic stellate cell activation induced by transforming growth factor-β1 (TGF-β1).

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.04.176

Abstract: Activated pancreatic stellate cells (PSCs) play a crucial role in the progression of pancreatic fibrosis. Transforming growth factor-β (TGF-β) is one of the strongest stimulator inducing fibrosis. The mitogen-activated protein kinase (MAPK) proteins (including ERK,… read more here.

Keywords: p38 mapk; psc activation; jnk erk; activation ... See more keywords

BPGAP1 spatially integrates JNK/ERK signaling crosstalk in oncogenesis

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recommendations! Published in 2017 at "Oncogene"

DOI: 10.1038/onc.2016.466

Abstract: Simultaneous hyperactivation of stress-activated protein kinase/c-Jun N-terminal protein kinase (SAPK/JNK) and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signaling cascades has been reported in carcinogenesis. However, how they are integrated to promote oncogenesis remains unknown.… read more here.

Keywords: jnk erk; kinase; erk; bpgap1 ... See more keywords
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Radix Paeoniae Rubra stimulates osteoclast differentiation by activation of the NF-κB and mitogen-activated protein kinase pathways

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recommendations! Published in 2018 at "BMC Complementary and Alternative Medicine"

DOI: 10.1186/s12906-018-2196-7

Abstract: BackgroundRadix Paeoniae Rubra (RPR), a traditional Chinese herb, has anti-inflammatory and immuno-regulatory properties. This study explored the effects of RPR on stimulation of osteoclast differentiation in RAW264.7 cells and peripheral blood mononuclear cells (PBMC)s.MethodsThe mature… read more here.

Keywords: jnk erk; osteoclast differentiation; paeoniae rubra; erk p38 ... See more keywords
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Nicotine alleviates MPTP-induced nigrostriatal damage through modulation of JNK and ERK signaling pathways in the mice model of Parkinson’s disease

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recommendations! Published in 2023 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2023.1088957

Abstract: Introduction: Nicotine (Nic) has previously been proven to reduce neurodegeneration in the models of Parkinson’s disease (PD). The present study is intended to investigate the detailed mechanisms related to the potential neuroprotective effects of Nic… read more here.

Keywords: signaling pathways; mptp induced; parkinson disease; jnk erk ... See more keywords
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Dehydrocrenatidine extracted from Picrasma quassioides induces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways

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recommendations! Published in 2021 at "Oncology Reports"

DOI: 10.3892/or.2021.8117

Abstract: Nasopharyngeal carcinoma (NPC) is an indicator disease in Asia due to its unique geographical and ethnic distribution. Dehydrocrenatidine (DC) is a β-carboline alkaloid abundantly present in Picrasma quassioides (D. Don) Benn, a deciduous shrub or… read more here.

Keywords: jnk erk; human npc; picrasma quassioides; apoptosis ... See more keywords
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HB-EGF induces mitochondrial dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca2+-FOXO1 pathway

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recommendations! Published in 2022 at "International Journal of Biological Sciences"

DOI: 10.7150/ijbs.69343

Abstract: Polycystic ovarian syndrome (PCOS) is one of the most prevalent endocrinopathies and the leading cause of anovulatory infertility, but its pathogenesis remains elusive. Although HB-EGF is involved in ovarian cancer progression, there is still no… read more here.

Keywords: egf; jnk erk; estrogen; camp pka ... See more keywords