Electrosprayed poly(lactic-co-glycolic acid) particles as a promising drug delivery system for the novel JNK inhibitor IQ-1.
Sign Up to like & getrecommendations! Published in 2020 at "European polymer journal"
DOI: 10.1016/j.eurpolymj.2020.109598
Abstract: Mitogen-activated protein kinases (MAPKs), including c-Jun N-terminal kinase (JNK), play important role in the regulation of pro-inflammatory cytokine secretion and signaling cascades. Therefore, JNKs are key targets for the treatment of cytokine/JNK-driven diseases. Herein, we… read more here.
Keywords: poly lactic; jnk; novel jnk; jnk inhibitor ... See more keywords
Abstract 5067: Suppression of tumorigenicity and metastasis of triple-negative breast cancer (TNBC) by c-Jun N-Terminal Kinase (JNK) inhibitor via reversing immunosuppressive tumor microenvironment (TME)
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-5067
Abstract: Immune checkpoint inhibitors (ICIs) is now a standard of care for metastatic TNBC, the most aggressive subtype of breast cancer. However, rates of tumor response to ICIs are low. Evidence suggests that an immunosuppressive TME… read more here.
Keywords: jnk; tnbc; tme; jnk inhibitor ... See more keywords
JNK inhibitor IX restrains pancreatic cancer through p53 and p21
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1006131
Abstract: Novel treatment options for pancreatic cancer are desperately needed. De-regulated kinases can be regularly detected in pancreatic cancer. Multiple pathway inhibitors were developed to exploit these features, among them selective inhibitors of the c-Jun N-terminal… read more here.
Keywords: pancreatic cancer; p53 p21; cancer; jnk inhibitor ... See more keywords