Circulating JNK pathway‐associated phosphatase: A novel biomarker correlates with Th17 cells, acute exacerbation risk, and severity in chronic obstructive pulmonary disease patients
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24153
Abstract: JNK pathway‐associated phosphatase (JKAP) involves in the regulation of inflammation, immunity, and lung injury. The current study aimed to investigate correlation of JKAP with Th1, Th17 cells, acute exacerbation risk, and disease severity in chronic… read more here.
Keywords: jnk pathway; th17 cells; cells acute; associated phosphatase ... See more keywords
LncRNA SNHG14 contributes to proinflammatory cytokine production in rheumatoid arthritis via the regulation of the miR-17-5p/MINK1-JNK pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental toxicology"
DOI: 10.1002/tox.23361
Abstract: Rheumatoid arthritis (RA) is a widespread autoimmune disorder of the joints. Long noncoding RNAs (lncRNAs) have been reported to participate in the pathogenesis of RA by serving as competitive endogenous RNAs. LncRNA small nucleolar RNA… read more here.
Keywords: mink1; mir; mir mink1; jnk pathway ... See more keywords
RhoA regulates Schwann cell differentiation through JNK pathway
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.06.013
Abstract: Abstract RhoA is a small GTPase that regulates many functions of mammalian cells via actin reorganization. Lots of studies uncovered that its activation acts as a major negative regulator of neurite extension, and inhibition of… read more here.
Keywords: schwann cell; differentiation; jnk pathway; rhoa ... See more keywords
Terminal differentiation of human granulosa cells as luteinization is reversed by activin-A through silencing of Jnk pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Cell death discovery"
DOI: 10.1038/s41420-020-00324-9
Abstract: Molecular mechanisms underlying luteinization (terminal differentiation of granulosa and theca cells after ovulation) and luteolysis (demise of corpus luteum) are poorly understood in human ovary. Here we report that activin-A, after binding to its cognate… read more here.
Keywords: granulosa cells; terminal differentiation; granulosa; jnk pathway ... See more keywords
Hyperoside exerts osteoprotective effect on dexamethasone-induced osteoblasts by targeting NADPH Oxidase 4 (NOX4) to inhibit the reactive oxygen species (ROS) accumulation and activate c-Jun N-terminal kinase (JNK) pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2054499
Abstract: ABSTRACT Hyperoside (Hyp) is a flavonoid active compound deriving from Chinese herbal medicines. Increasing studies have implicated that Hyp may serve as a predominant promoting factor in osteoblast differentiation. This paper investigates whether Hyp could… read more here.
Keywords: hyp; induced cells; dex; jnk pathway ... See more keywords
Transient Inhibition of the JNK Pathway Promotes Human Hematopoietic Stem Cell Quiescence and Engraftment.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells translational medicine"
DOI: 10.1093/stcltm/szac019
Abstract: The widespread clinical application of cord blood (CB) for hematopoietic stem cell (HSC) transplantation is limited mainly by the inadequate number of hematopoietic stem and progenitor cells (HSPCs) in single CB units, which results in… read more here.
Keywords: inhibition jnk; cell; jnk pathway; transient inhibition ... See more keywords
JNK pathway plays a critical role for expansion of human colorectal cancer in the context of BRG1 suppression
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15520
Abstract: Tumor stem cells (TSCs), capable of self‐renewal and continuous production of progeny cells, could be potential therapeutic targets. We have recently reported that chromatin remodeling regulator Brg1 is required for maintenance of murine intestinal TSCs… read more here.
Keywords: jnk pathway; brg1 suppression; human crc; suppression ... See more keywords
Calcium phytate reverses high glucose-inhibited osteogenesis of BMSCs via the MAPK/JNK pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Oral diseases"
DOI: 10.1111/odi.14598
Abstract: OBJECTIVES Diabetes mellitus (DM) induces oxidative tissue impairment and suppresses bone formation. Some studies have shown that phytic acid has antioxidant and anti-diabetic properties. This study aimed to investigate the potential of calcium phytate (Ca-phytate)… read more here.
Keywords: inhibited osteogenesis; jnk pathway; jnk; mapk jnk ... See more keywords
Role of the JNK Pathway in Varicella-Zoster Virus Lytic Infection and Reactivation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00640-17
Abstract: ABSTRACT Mechanisms of neuronal infection by varicella-zoster virus (VZV) have been challenging to study due to the relatively strict human tropism of the virus and the paucity of tractable experimental models. Cellular mitogen-activated protein kinases… read more here.
Keywords: jnk; infection; reactivation; role ... See more keywords
MicroRNA-10b Promotes Apoptosis via JNK Pathway in Clear Cell Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Nephron"
DOI: 10.1159/000486017
Abstract: Background/Aims: To investigate the downregulation of microRNA (miR)-10b in clear cell renal cell carcinoma (ccRCC) and its mechanistic involvement in tumourigenesis. Methods: The relative expression of miR-10b in ccRCC samples were determined by real-time PCR.… read more here.
Keywords: mir 10b; cell; jnk pathway; apoptosis ... See more keywords
Metformin Inhibits Proliferation of Human Thyroid Cancer TPC-1 Cells by Decreasing LRP2 to Suppress the JNK Pathway
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s227915
Abstract: Objective To uncover the potential effect of metformin on proliferation and apoptosis of thyroid cancer TPC-1 cell line, and the underlying mechanism. Methods Viability, apoptosis and LRP2 level in TPC-1 cells treated with different doses… read more here.
Keywords: tpc; tpc cells; jnk pathway; metformin ... See more keywords