Sirt1 alleviates LPS induced inflammation of periodontal ligament fibroblasts via downregulation of TLR4.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.07.099
Abstract: This study was aimed to investigate the role of Sirt1 in LPS-injured periodontal ligament fibroblast (PDLF), to evaluate potential functions of Sirt1 in the pathogenesis of periodontitis. Sirt1 overexpression significantly increased cell viability, Ki67 positive… read more here.
Keywords: sirt1; periodontal ligament; sirt1 alleviates; alleviates lps ... See more keywords
Excess Palmitate Induces Decidual Stromal Cell Apoptosis Via the TLR4/JNK/NF-kB Pathways and Possibly through Glutamine Oxidation.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaaa004
Abstract: During gestation, excess palmitate (PA) is enriched in decidua. Both excess PA and decidual dysfunctions are associated with numerous adverse pregnancy outcomes such as gestational diabetes, preeclampsia and preterm birth, and intrauterine growth restriction. Here,… read more here.
Keywords: tlr4 jnk; oxidation; apoptosis; tlr4 ... See more keywords
MMPP Exerts Anti-Inflammatory Effects by Suppressing MD2-Dependent NF-κB and JNK/AP-1 Pathways in THP-1 Monocytes
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16040480
Abstract: (E)-2-methoxy-4-[3-(4-methoxyphenyl) prop-1-en-1-yl] phenol (MMPP), a novel synthetic analog of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal (BHPB), exerts anti-inflammatory and anticancer effects by downregulating the STAT3 pathway. It has also been recently reported that MMPP can act as a PPAR agonist… read more here.
Keywords: exerts anti; mmpp; thp monocytes; jnk pathways ... See more keywords