Involvement of mTOR, JNK and PI3K in the negative effect of ethanol and metformin on the human first‐trimester extravillous trophoblast HTR‐8/SVneo cell line
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.05.038
Abstract: Abstract Our aim was to investigate the effect of two xenobiotics to which pregnant woman may be exposed, the drug of abuse ethanol (EtOH) (and its metabolite acetaldehyde (ACA)) and the therapeutic agent metformin (METF),… read more here.
Keywords: metf; jnk pi3k; htr svneo; mtor jnk ... See more keywords
Orientin-mediated Nrf2/HO-1 signal alleviates H2O2-induced oxidative damage via induction of JNK and PI3K/AKT activation.
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DOI: 10.1016/j.ijbiomac.2018.06.130
Abstract: Oxidative stress is closely associated with the pathogenesis of various diseases. Orientin (Ori), a flavonoid component isolated from natural plants, possesses antioxidant activity. Accordingly, we focused on exploring the potential therapeutic effects of Ori on… read more here.
Keywords: jnk pi3k; pi3k; jnk; pi3k akt ... See more keywords
Microbial Fermentation-Derived Dihydroquercetin Derivatives Exhibit Superior Efficacy in Ameliorating Insulin Resistance via JNK/PI3K/AKT Pathway Regulation Compared to Dihydroquercetin.
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DOI: 10.1021/acs.jafc.5c00109
Abstract: Insulin resistance (IR) is a complex metabolic disorder characterized by diminished insulin sensitivity, leading to impaired glucose uptake and a potential progression to hyperglycemia and diabetes. While lifestyle modifications are essential, the limitations of current… read more here.
Keywords: microbial fermentation; insulin resistance; dhq; jnk pi3k ... See more keywords