G2 and S phase‐expressed‐1 induces chromosomal instability in esophageal squamous cell carcinoma cells and inhibits cell apoptosis through ROS/JNK signaling
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23470
Abstract: New diagnostic and therapeutic strategies are urgently needed to improve the prognosis of patients with esophageal squamous cell carcinoma (ESCC), which has high morbidity and mortality. Bioinformatics analysis revealed that cell cycle regulation related molecular… read more here.
Keywords: cell; apoptosis; jnk signaling; gtse1 ... See more keywords
Tankyrase regulates apoptosis by activating JNK signaling in Drosophila.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.06.143
Abstract: Programmed cell death (PCD), or apoptosis, plays essential roles in various cellular and developmental processes, and dysregulation of apoptosis causes many diseases. Thus, regulation of apoptotic process is very important. Drosophila tankyrase (DTNKS) is an… read more here.
Keywords: apoptosis activating; activating jnk; apoptosis; jnk signaling ... See more keywords
EGb761 ameliorates cell necroptosis by attenuating RIP1-mediated mitochondrial dysfunction and ROS production in both in vivo and in vitro models of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2020.146730
Abstract: OBJECTIVES To investigate the neuroprotective effect of Gingko biloba extract 761 (EGb761) in Alzheimer's disease (AD) models both in vivo and in vitro and the underlying molecular mechanism. METHODS Cultured BV2 microglial cells were treated… read more here.
Keywords: vivo vitro; alzheimer disease; jnk signaling; cognitive function ... See more keywords
JNK signaling contributes to skeletal muscle wasting and protein turnover in pancreatic cancer cachexia.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.07.025
Abstract: Cancer cachexia patients experience significant muscle wasting, which impairs the quality of life and treatment efficacy for patients. Skeletal muscle protein turnover is imparted by increased expression of ubiquitin-proteasome pathway components. Mitogen-activated protein kinases p38… read more here.
Keywords: cancer; muscle; jnk signaling; cancer cachexia ... See more keywords
Cadmium‐induced apoptosis through reactive oxygen species‐mediated mitochondrial oxidative stress and the JNK signaling pathway in TM3 cells, a model of mouse Leydig cells
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2019.02.012
Abstract: Abstract Cadmium (Cd) is a heavy metal that widely exists in the environment and industry, and which causes serious damages to reproductive system. Recent studies have reported that cadmium induces apoptosis of various germ cells… read more here.
Keywords: cadmium induced; apoptosis; jnk; cadmium ... See more keywords
XEDAR inhibits the proliferation and induces apoptosis of gastric cancer cells by regulating JNK signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20192726
Abstract: Abstract X-linked ectodermal dysplasia receptor (XEDAR) has been widely studied in epidermal morphogenesis, but few studies have been conducted on tumorigenesis and development, including gastric cancer. In the present research, we aimed to investigate the… read more here.
Keywords: xedar; cancer; gastric cancer; signaling pathway ... See more keywords
Non-kinase targeting of oncogenic c-Jun N-terminal kinase (JNK) signaling: the future of clinically viable cancer treatments
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20220808
Abstract: c-Jun N-terminal Kinases (JNKs) have been identified as key disease drivers in a number of pathophysiological settings and central oncogenic signaling nodes in various cancers. Their roles in driving primary tumor growth, positively regulating cancer… read more here.
Keywords: jnk signaling; jun terminal; jnk; non kinase ... See more keywords
HER2-driven breast cancer suppression by the JNK signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2218373120
Abstract: Significance The cJun NH2-terminal kinase (JNK) signaling pathway has been implicated in the etiology of breast cancer because mutations in the JNK pathway have been identified in tumors. To test the role of the JNK… read more here.
Keywords: jnk signaling; breast cancer; cancer; signaling pathway ... See more keywords
LINC00313 alleviates osteoarthritis progression in mice through promoting TRAF1 promoter methylation and inhibiting the ASK1/JNK signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2078728
Abstract: Abstract Objectives This study aimed to explore the underlying role and mechanism of LINC00313 in osteoarthritis (OA) progression. Methods CHON-001 chondrocytes were treated with interleukin (IL)-1β to induce OA in vitro, and then transfected with… read more here.
Keywords: signaling pathway; promoter methylation; jnk signaling; jnk ... See more keywords
Hepatitis C Virus-Induced ROS/JNK Signaling Pathway Activates the E3 Ubiquitin Ligase Itch to Promote the Release of HCV Particles via Polyubiquitylation of VPS4A
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01811-21
Abstract: The ROS/JNK signaling pathway contributes to liver diseases, including steatosis, metabolic disorders, and hepatocellular carcinoma. We previously reported that HCV activates the ROS/JNK signaling pathway, leading to the enhancement of hepatic gluconeogenesis and apoptosis induction.… read more here.
Keywords: signaling pathway; ros jnk; jnk signaling; hcv ... See more keywords
JNK Signaling Promotes Bladder Cancer Immune Escape by Regulating METTL3-Mediated m6A Modification of PD-L1 mRNA.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-1323
Abstract: The RNA N6-methyladenosine (m6A) writer methyltransferase-like 3 (METTL3) is upregulated in many types of cancer and promotes cancer progression by increasing expression of several oncogenes. Therefore, a better understanding of the mechanisms regulating METTL3 expression… read more here.
Keywords: expression; jnk signaling; mettl3; bladder cancer ... See more keywords