Inhibiting the Piezo1 channel protects microglia from acute hyperglycaemia damage through the JNK1 and mTOR signalling pathways.
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DOI: 10.1016/j.lfs.2020.118667
Abstract: AIM Diabetes is a high-risk factor for neurocognitive dysfunction. Diabetic acute hyperglycaemia accompanied by high osmotic pressure can induce immune cell dysfunction, but its mechanism of action in brain microglia remains unclear. This study aimed… read more here.
Keywords: piezo1; hyperglycaemia; acute hyperglycaemia; jnk1 mtor ... See more keywords