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   Articles with "jnk3" as a keyword



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Anxiety in rats with bile duct ligation is associated with activation of JNK3 mitogen-activated protein kinase in the hippocampus

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recommendations! Published in 2020 at "Metabolic Brain Disease"

DOI: 10.1007/s11011-020-00542-1

Abstract: We examine the anxiety-like behaviors in rats with bile duct ligation (BDL), as well as its relationship with the expression of JNK3 and P38 MAPKs in rat hippocampus. Male Wistar rats undergo either sham operation… read more here.

Keywords: rats bile; hippocampus; anxiety; bile duct ... See more keywords
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JNK3 phosphorylates Bax protein and induces ability to form pore on bilayer lipid membrane

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recommendations! Published in 2017 at "Biochimie Open"

DOI: 10.1016/j.biopen.2017.02.001

Abstract: Bax is a pro-apoptotic cytosolic protein. In this work native (unphosphorylated) and JNK3 phosphorylated Bax proteins are studied on artificial bilayer membranes for pore formation. Phosphorylated Bax formed pore on the bilayer lipid membrane whereas… read more here.

Keywords: phosphorylated bax; pore bilayer; jnk3; bilayer lipid ... See more keywords
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Targeting the Dvl-1/β-arrestin2/JNK3 interaction disrupts Wnt5a-JNK3 signaling and protects hippocampal CA1 neurons during cerebral ischemia reperfusion

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recommendations! Published in 2018 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2018.03.006

Abstract: &NA; It is well known that Wnt5a activation plays a pivotal role in brain injury and &bgr;‐arrestin2 induces c‐Jun N‐terminal kinase (JNK3) activation is involved in neuronal cell death. Nonetheless, the relationship between Wnt5a and… read more here.

Keywords: arrestin2; jnk3 signaling; bgr arrestin2; jnk3 ... See more keywords
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Discovery of Novel Indazole Chemotypes as Isoform-Selective JNK3 Inhibitors for the Treatment of Parkinson's Disease.

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recommendations! Published in 2023 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.2c01410

Abstract: c-Jun N-terminal kinases (JNKs) are involved in the pathogenesis of various diseases. In particular, JNK3 and not JNK1/2 is primarily expressed in the brain and plays a key role in mediating neurodegenerative diseases like Parkinson's… read more here.

Keywords: isoform selective; jnk3; parkinson disease; jnk3 inhibitors ... See more keywords
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JNK3 Overexpression in the Entorhinal Cortex Impacts on the Hippocampus and Induces Cognitive Deficiencies and Tau Misfolding.

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recommendations! Published in 2023 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.3c00092

Abstract: c-Jun N-terminal kinases (JNKs) are a family of protein kinases activated by a myriad of stimuli consequently modulating a vast range of biological processes. In human postmortem brain samples affected with Alzheimer′s disease (AD), JNK… read more here.

Keywords: jnk3 overexpression; entorhinal cortex; overexpression entorhinal; jnk3 ... See more keywords
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Thiophene-Pyrazolourea Derivatives as Potent, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors

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recommendations! Published in 2021 at "ACS Medicinal Chemistry Letters"

DOI: 10.1021/acsmedchemlett.0c00533

Abstract: Potent JNK3 isoform selective inhibitors were developed from a thiophenyl-pyrazolourea scaffold. Through structure activity relationship (SAR) studies utilizing enzymatic and cell-based assays, and in vitro and in vivo drug metabolism and pharmacokinetic (DMPK) studies, potent… read more here.

Keywords: orally bioavailable; jnk3 inhibitors; selective jnk3; jnk3 ... See more keywords
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Radiolabeled Aminopyrazoles as Novel Isoform Selective Probes for pJNK3 Quantification.

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recommendations! Published in 2022 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.2c00278

Abstract: The c-Jun N-terminal kinase 3 (JNK3) is a stress-activated kinase primarily expressed in the brain and implicated as an early mediator of neuronal apoptosis. We sought to develop a PET tracer to visualize pathological JNK3… read more here.

Keywords: jnk3 activation; jnk3; radiolabeled aminopyrazoles; aminopyrazoles novel ... See more keywords
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Identifying New Ligands for JNK3 by Fluorescence Thermal Shift Assays and Native Mass Spectrometry

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recommendations! Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.2c00340

Abstract: The c-Jun N-terminal kinases (JNKs) are evolutionary highly conserved serine/threonine kinases. Numerous findings suggest that JNK3 is involved in the pathogenesis of neurodegenerative diseases, so the inhibition of JNK3 may be a potential therapeutic intervention.… read more here.

Keywords: native mass; mass spectrometry; jnk3; thermal shift ... See more keywords
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Proposing the Promiscuous Protein Structures in JNK1 and JNK3 for Virtual Screening in Pursuit of Potential Leads

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recommendations! Published in 2020 at "ACS Omega"

DOI: 10.1021/acsomega.9b03458

Abstract: Over the past decade, the available crystal structures have almost doubled in Protein Data Bank (PDB) providing the research community with a series of similar crystal structures to choose from for future docking studies. With… read more here.

Keywords: virtual screening; protein structures; docking studies; proposing promiscuous ... See more keywords
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New insights into the structural dynamics of the kinase JNK3

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-27867-3

Abstract: In this work, we study the dynamics and the energetics of the all-atom structure of a neuronal-specific serine/threonine kinase c-Jun N-terminal kinase 3 (JNK3) in three states: unphosphorylated, phosphorylated, and ATP-bound phosphorylated. A series of… read more here.

Keywords: dynamics kinase; structural dynamics; jnk3; new insights ... See more keywords
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Colocalization and Interaction Study of Neuronal JNK3, JIP1, and β-Arrestin2 Together with PSD95

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23084113

Abstract: c-Jun N-terminal kinases (JNKs) are stress-activated serine/threonine protein kinases belonging to the mitogen-activated protein kinase (MAPK) family. Among them, JNK3 is selectively expressed in the central nervous system, cardiac smooth muscle, and testis. In addition,… read more here.

Keywords: jip1 arrestin2; together psd95; colocalization; jip1 ... See more keywords