Impact of switching oral bisphosphonates to denosumab or daily teriparatide on the progression of radiographic joint destruction in patients with biologic-naïve rheumatoid arthritis
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DOI: 10.1007/s00198-018-4492-y
Abstract: SummaryIn biologic-naïve female RA patients, switching oral BPs to DMAb significantly reduced radiographic joint destruction compared to continuing oral BPs or switching to TPTD at 12 months, which were significantly associated with a decrease of a… read more here.
Keywords: radiographic joint; dmab; group; switching oral ... See more keywords
Time-averaged disease activity fits better joint destruction in rheumatoid arthritis
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DOI: 10.1038/s41598-017-05581-w
Abstract: Disease activity of rheumatoid arthritis (RA), evaluated as Disease Activity Score (DAS), is associated with joint destruction. Since joint destruction reflects the history of disease activities, we hypothesized that time-averaged disease activity would better correlate… read more here.
Keywords: time averaged; time; disease; disease activity ... See more keywords
Efficacy of golimumab for preventing large joint destruction in patients with rheumatoid arthritis as determined by the ARASHI score
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DOI: 10.1080/14397595.2017.1280113
Abstract: Abstract Objectives: The objective of this study is to investigate the inhibitory effect of golimumab on large joint destruction in patients with rheumatoid arthritis. Methods: We recruited 45 patients with rheumatoid arthritis and evaluated the… read more here.
Keywords: large joint; golimumab; rheumatoid arthritis; score ... See more keywords
Suppression of joint destruction with subcutaneous tocilizumab for Japanese patients with rheumatoid arthritis in clinical practice
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DOI: 10.1080/14397595.2019.1676369
Abstract: Abstract Objectives: To investigate the efficacy of suppressing joint destruction with subcutaneous tocilizumab (TCZ-SC) for Japanese rheumatoid arthritis (RA) patients in the real-world clinical setting. Methods: This 1-year prospective, multicenter study included 110 RA patients… read more here.
Keywords: disease activity; joint destruction; remission; destruction subcutaneous ... See more keywords
Region specificity of rheumatoid foot symptoms associated with ultrasound-detected synovitis and joint destruction.
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DOI: 10.1080/14397595.2021.1912905
Abstract: OBJECTIVES We aimed to clarify the clinical implication of ultrasound (US)-detected foot joint inflammation in tightly controlled patients with rheumatoid arthritis (RA). METHODS We evaluated bilateral foot joints (second to fifth metatarsophalangeal joints of forefoot;… read more here.
Keywords: ultrasound detected; detected synovitis; foot; joint destruction ... See more keywords
Leonurine attenuates fibroblast-like synoviocyte-mediated synovial inflammation and joint destruction in rheumatoid arthritis
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DOI: 10.1093/rheumatology/kex142
Abstract: Objective To explore the role of leonurine in the regulation of synovial inflammation and joint destruction inRA. Methods Fibroblast-like synoviocytes were isolated from synovial tissue from RA patients. Pro-inflammatory cytokine and MMP expression was evaluated… read more here.
Keywords: inflammation joint; synovial inflammation; joint destruction; leonurine ... See more keywords
Serological biomarkers detect active joint destruction and inflammation in patients with haemophilic arthropathy
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DOI: 10.1111/hae.13196
Abstract: Progressive arthropathy caused by recurrent joint bleeds is a severe complication in haemophilia. read more here.
Keywords: destruction inflammation; active joint; detect active; biomarkers detect ... See more keywords
AB0235 Polymorphisms of hla-drb1 and tnf-308 g/a are associated with radiographic joint destruction in patients with very early rheumatoid arthritis
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DOI: 10.1136/annrheumdis-2018-eular.2515
Abstract: Objectives To clarify the association between HLA-DRB1 and TNFα (−308G>A) genes polymorphism and joint destruction/further progression during 12 months of the follow-up period (FUP) in patients with early ( read more here.
Keywords: patients early; destruction; hla drb1; progression ... See more keywords
AB0326 Matrix metalloproteinase-3 is a good predictor for joint destruction only in male patients with rheumatoid arthritis
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DOI: 10.1136/annrheumdis-2018-eular.2835
Abstract: Background Serum level of matrix metalloproteinase-3 (MMP-3) is elevated by synovial inflammation. It destroys articular cartilage such as proteoglycans so that it has been used as a clinical biomarker of joint destruction in patients with… read more here.
Keywords: predictor joint; destruction; male; mmp ... See more keywords
P073 Regulation of joint destruction by activin a in rheumatoid arthritis
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DOI: 10.1136/annrheumdis-2018-ewrr2018.90
Abstract: Introduction Activins and inhibins belong to the transforming growth factor β family. Activins are disulphide-linked homo- or heterodimers consisting of two inhibin β chains (βA, βB) that are expressed in many cell types. However, activin… read more here.
Keywords: differentiation; rheumatoid arthritis; arthritis; joint destruction ... See more keywords
The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis
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DOI: 10.3389/fcell.2022.1011371
Abstract: Rheumatoid arthritis (RA) is a systemic autoimmune disease accompanied with joint destruction. Serious joint destruction will eventually lead to disability and the decline of life quality in RA patients. At present, the therapeutic effect of… read more here.
Keywords: long non; coding rnas; rheumatoid arthritis; joint destruction ... See more keywords