Signaling networks in joint development
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24472
Abstract: Here we review studies identifying regulatory networks responsible for synovial, cartilaginous, and fibrous joint development. Synovial joints, characterized by the fluid‐filled synovial space between the bones, are found in high‐mobility regions and are the most… read more here.
Keywords: networks joint; signaling networks; development; joint development ... See more keywords
Defective Joint Development and Maintenance in GDF6‐Related Multiple Synostoses Syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4785
Abstract: Multiple synostoses syndromes (SYNS) are a group of rare genetic bone disorders characterized by multiple joint fusions. We previously reported an SYNS4‐causing GDF6 c.1330 T > A (p.Tyr444Asn) mutation, which reduced Noggin‐induced GDF6 inhibition and enhanced SMAD1/5/8 signaling.… read more here.
Keywords: gdf6 tyr443asn; multiple synostoses; gdf6; joint development ... See more keywords