Pathogenic stromal cells as therapeutic targets in joint inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-018-0112-7
Abstract: Knowledge of how the joint functions as an integrated unit in health and disease requires an understanding of the stromal cells populating the joint mesenchyme, including fibroblasts, tissue-resident macrophages and endothelial cells. Knowledge of the… read more here.
Keywords: cells mesenchymal; stromal cells; inflammation; mesenchymal origin ... See more keywords
Evaluation of conjugated linoleic acid supplementation on markers of joint inflammation and cartilage metabolism in young horses challenged with lipopolysaccharide.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of animal science"
DOI: 10.1093/jas/skx076
Abstract: Seventeen yearling Quarter Horses were used in a randomized complete block design for a 56-d trial to determine ability of dietary CLA to mitigate joint inflammation and alter cartilage turnover following an inflammatory insult. Horses… read more here.
Keywords: joint inflammation; synovial fluid; cla; cartilage ... See more keywords
Assessment of inflammation in patients with rheumatoid arthritis using thermography and machine learning: a fast and automated technique
Sign Up to like & getrecommendations! Published in 2022 at "RMD Open"
DOI: 10.1136/rmdopen-2022-002458
Abstract: Objectives Sensitive detection of joint inflammation in rheumatoid arthritis (RA) is crucial to the success of the treat-to-target strategy. In this study, we characterise a novel machine learning-based computational method to automatically assess joint inflammation… read more here.
Keywords: inflammation; using thermography; machine learning; rheumatoid arthritis ... See more keywords
Patterns of clinical joint inflammation in juvenile idiopathic arthritis
Sign Up to like & getrecommendations! Published in 2023 at "RMD Open"
DOI: 10.1136/rmdopen-2022-002941
Abstract: Objectives We studied patterns of joint inflammation in juvenile idiopathic arthritis (JIA) to assess whether joint activity recurs locally in the same joints. Methods Joints of 91 patients of the BeSt for Kids study, a… read more here.
Keywords: inflammation; inflammation juvenile; joint inflammation; idiopathic arthritis ... See more keywords
Vasoinhibin is Generated and Promotes Inflammation in Mild Antigen-Induced Arthritis.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac036
Abstract: Inflammatory arthritis defines a family of diseases influenced by reproductive hormones. Vasoinhibin, a fragment of the hormone prolactin (PRL), has antiangiogenic and proinflammatory properties. We recently showed that vasoinhibin reduces joint inflammation and bone loss… read more here.
Keywords: joint inflammation; arthritis; vasoinhibin; induced arthritis ... See more keywords
Secretive derived from hypoxia preconditioned mesenchymal stem cells promote cartilage regeneration and mitigate joint inflammation via extracellular vesicles.
Sign Up to like & getrecommendations! Published in 2023 at "Bioactive materials"
DOI: 10.2139/ssrn.4267283
Abstract: Secretome derived from mesenchymal stem cells (MSCs) have profound effects on tissue regeneration, which could become the basis of future MSCs therapies. Hypoxia, as the physiologic environment of MSCs, has great potential to enhance MSCs… read more here.
Keywords: regeneration; inflammation; joint inflammation; mesenchymal stem ... See more keywords
Sensory Ganglia-Specific TNF Expression Is Associated With Persistent Nociception After Resolution of Inflammation
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.03120
Abstract: Joint pain is a distressing symptom of arthritis, and it is frequently persistent even after treatments which reduce local inflammation. Continuous production of algogenic factors activate/sensitize nociceptors in the joint structures and contribute to persistent… read more here.
Keywords: resolution; drg; inflammation; joint inflammation ... See more keywords
The effect of JuanBiQiangGu granules in combination with methotrexate on joint inflammation in rheumatoid arthritis: a randomized controlled trial
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1132602
Abstract: Background: Rheumatoid arthritis (RA) joint inflammation severely affects joint function and quality of life in patients and leads to joint deformities and limb disability. The non-steroidal anti-inflammatory drugs used in the treatment of RA do… read more here.
Keywords: group; mtx group; joint inflammation; jbqg group ... See more keywords
Inhibition of TREM-2 Markedly Suppresses Joint Inflammation and Damage in Experimental Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23168857
Abstract: The triggering receptors expressed on myeloid cells (TREMs) are a family of activating immune receptors that regulate the inflammatory response. TREM-1, which is expressed on monocytes and/or macrophages and neutrophils, functions as an inflammation amplifier… read more here.
Keywords: trem; inflammation damage; joint inflammation; arthritis ... See more keywords
Mitochondria-targeted supramolecular coordination container encapsulated with exogenous itaconate for synergistic therapy of joint inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.70623
Abstract: Rationale: Inflammatory macrophages and osteoclasts (OCs) play critical roles in joint inflammation, which feature the excessive production of reactive oxygen species (ROS), resulting in synovial inflammation and bone erosion. Scavenging ROS, especially by modulating mitochondrial… read more here.
Keywords: inflammation; ros scavenging; targeted supramolecular; mitochondria targeted ... See more keywords