Integrated Cascade Nanozyme Remodels Chondrocyte Inflammatory Microenvironment in Temporomandibular Joint Osteoarthritis via Inhibiting ROS‐NF‐κB and MAPK Pathways
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202203195
Abstract: Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative joint disease with no complete cure at present. Notably, the inflammatory microenvironment in TMJ OA is modulated by oxidative stress, which impacts cartilage metabolism, chondrocyte apoptosis, inflammatory… read more here.
Keywords: inhibiting ros; microenvironment; inflammatory microenvironment; temporomandibular joint ... See more keywords
Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202501046
Abstract: Facet joint osteoarthritis (FJOA) is a prevalent degenerative condition in the aging population; however, the underlying pathophysiological mechanisms remain poorly understood and current therapeutic strategies remain limited to palliative pain management. In this study, novel… read more here.
Keywords: facet joint; non canonical; joint osteoarthritis; talin2 ... See more keywords
Necroptotic TNFα‐Syndecan 4‐TNFα Vicious Cycle as a Therapeutic Target for Preventing Temporomandibular Joint Osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4542
Abstract: Temporomandibular joint osteoarthritis (TMJOA) is a chronic degenerative disease for which the underlying mechanism still remains unclear. Compared with apoptosis and autophagy, necroptosis causes greater harm to tissue homeostasis by releasing damage‐associated molecular patterns (DAMPs).… read more here.
Keywords: necroptosis; vicious cycle; therapeutic target; tnf ... See more keywords
Patients' Perspectives on Participation in an Effectiveness Study on Footwear Modification for the First Metatarsophalangeal Joint Osteoarthritis: A Qualitative Study
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Foot and Ankle Research"
DOI: 10.1002/jfa2.70050
Abstract: The effectiveness of footwear modifications for the first metatarsophalangeal (MTP) joint osteoarthritis (OA) compared to usual general practitioner (GP) care has never been studied. Understanding patients' perspectives is essential for assessing the feasibility of a… read more here.
Keywords: patients perspectives; first metatarsophalangeal; effectiveness; joint osteoarthritis ... See more keywords
Transcatheter Arterial Embolization as a Treatment for Chronic Pain due to Temporomandibular Joint Osteoarthritis
Sign Up to like & getrecommendations! Published in 2025 at "Cardiovascular and Interventional Radiology"
DOI: 10.1007/s00270-025-04008-8
Abstract: To assess the efficacy and safety of transarterial embolization (TAE) for the treatment of temporomandibular joint osteoarthritis (TMJ-OA)-related symptoms. Three female patients were referred to our center for TAE after conservative and surgical TMJ treatments… read more here.
Keywords: joint osteoarthritis; temporomandibular joint; embolization; treatment ... See more keywords
MiR-337-3p confers protective effect on facet joint osteoarthritis by targeting SKP2 to inhibit DUSP1 ubiquitination and inactivate MAPK pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology and toxicology"
DOI: 10.1007/s10565-021-09665-2
Abstract: OBJECTIVE To probe the performance of miR-337-3p on the facet joint osteoarthritis (FJOA) and its underlying mechanism. METHODS qRT-PCR and Western blot were utilized to analyze the levels of miR-337-3p and DUSP1 in the synovial… read more here.
Keywords: mir 337; dusp1; facet joint; joint osteoarthritis ... See more keywords
MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.02.006
Abstract: The efficacy of mesenchymal stem cell (MSC) therapies is increasingly attributed to paracrine secretion, particularly exosomes. In this study, we investigated the role of MSC exosomes in the regulation of inflammatory response, nociceptive behaviour, and… read more here.
Keywords: joint osteoarthritis; inflammation; temporomandibular joint; msc exosomes ... See more keywords
Quantitative bone imaging biomarkers to diagnose temporomandibular joint osteoarthritis.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of oral and maxillofacial surgery"
DOI: 10.1016/j.ijom.2020.04.018
Abstract: Bone degradation of the condylar surface is seen in temporomandibular joint osteoarthritis (TMJ OA); however, the initial changes occur in the subchondral bone. This cross-sectional study was performed to evaluate 23 subchondral bone imaging biomarkers… read more here.
Keywords: imaging biomarkers; bone imaging; temporomandibular joint; subchondral bone ... See more keywords
Effects of Mechanical Stress and Deficiency of Dihydrotestosterone or 17β-Estradiol on Temporomandibular Joint Osteoarthritis in Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2021.08.005
Abstract: OBJECTIVE To observe and analyze the interaction between excessive mechanical stress (MS) and decreased sex hormones on Temporomandibular Joint Osteoarthritis (TMJ-OA), and to discover TMJ-OA disease susceptibility genes by molecular biological analysis to elucidate part… read more here.
Keywords: mechanical stress; osteoarthritis; temporomandibular joint; mice ... See more keywords
Systematic review of studies on drug-delivery systems for management of temporomandibular-joint osteoarthritis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of stomatology, oral and maxillofacial surgery"
DOI: 10.1016/j.jormas.2021.08.003
Abstract: INTRODUCTION Temporomandibular-joint osteoarthritis (TMJOA) management is a major challenge. Minimally invasive therapies (based mainly on injections) have been developed to increase local efficacy and limit adverse systemic effects. However, the requirement for repeat injections due… read more here.
Keywords: delivery; temporomandibular joint; management; drug ... See more keywords
Efficient Delivery of siRNA via Tetrahedral Framework Nucleic Acids: Inflammation Attenuation and Matrix Regeneration in Temporomandibular Joint Osteoarthritis.
Sign Up to like & getrecommendations! Published in 2024 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.4c11089
Abstract: Temporomandibular joint osteoarthritis (TMJOA) is the most common and severe subtype of temporomandibular disease characterized by inflammation and cartilage matrix degradation. Compared with traditional conservative treatment, small interfering RNAs (siRNAs) have emerged as a more… read more here.
Keywords: temporomandibular joint; tetrahedral framework; tmjoa; sirna ... See more keywords