Integrated Cascade Nanozyme Remodels Chondrocyte Inflammatory Microenvironment in Temporomandibular Joint Osteoarthritis via Inhibiting ROS‐NF‐κB and MAPK Pathways
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202203195
Abstract: Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative joint disease with no complete cure at present. Notably, the inflammatory microenvironment in TMJ OA is modulated by oxidative stress, which impacts cartilage metabolism, chondrocyte apoptosis, inflammatory… read more here.
Keywords: inhibiting ros; microenvironment; inflammatory microenvironment; temporomandibular joint ... See more keywords
Necroptotic TNFα‐Syndecan 4‐TNFα Vicious Cycle as a Therapeutic Target for Preventing Temporomandibular Joint Osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4542
Abstract: Temporomandibular joint osteoarthritis (TMJOA) is a chronic degenerative disease for which the underlying mechanism still remains unclear. Compared with apoptosis and autophagy, necroptosis causes greater harm to tissue homeostasis by releasing damage‐associated molecular patterns (DAMPs).… read more here.
Keywords: necroptosis; vicious cycle; therapeutic target; tnf ... See more keywords
MiR-337-3p confers protective effect on facet joint osteoarthritis by targeting SKP2 to inhibit DUSP1 ubiquitination and inactivate MAPK pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology and toxicology"
DOI: 10.1007/s10565-021-09665-2
Abstract: OBJECTIVE To probe the performance of miR-337-3p on the facet joint osteoarthritis (FJOA) and its underlying mechanism. METHODS qRT-PCR and Western blot were utilized to analyze the levels of miR-337-3p and DUSP1 in the synovial… read more here.
Keywords: mir 337; dusp1; facet joint; joint osteoarthritis ... See more keywords
MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.02.006
Abstract: The efficacy of mesenchymal stem cell (MSC) therapies is increasingly attributed to paracrine secretion, particularly exosomes. In this study, we investigated the role of MSC exosomes in the regulation of inflammatory response, nociceptive behaviour, and… read more here.
Keywords: joint osteoarthritis; inflammation; temporomandibular joint; msc exosomes ... See more keywords
Quantitative bone imaging biomarkers to diagnose temporomandibular joint osteoarthritis.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of oral and maxillofacial surgery"
DOI: 10.1016/j.ijom.2020.04.018
Abstract: Bone degradation of the condylar surface is seen in temporomandibular joint osteoarthritis (TMJ OA); however, the initial changes occur in the subchondral bone. This cross-sectional study was performed to evaluate 23 subchondral bone imaging biomarkers… read more here.
Keywords: imaging biomarkers; bone imaging; temporomandibular joint; subchondral bone ... See more keywords
Effects of Mechanical Stress and Deficiency of Dihydrotestosterone or 17β-Estradiol on Temporomandibular Joint Osteoarthritis in Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2021.08.005
Abstract: OBJECTIVE To observe and analyze the interaction between excessive mechanical stress (MS) and decreased sex hormones on Temporomandibular Joint Osteoarthritis (TMJ-OA), and to discover TMJ-OA disease susceptibility genes by molecular biological analysis to elucidate part… read more here.
Keywords: mechanical stress; osteoarthritis; temporomandibular joint; mice ... See more keywords
Systematic review of studies on drug-delivery systems for management of temporomandibular-joint osteoarthritis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of stomatology, oral and maxillofacial surgery"
DOI: 10.1016/j.jormas.2021.08.003
Abstract: INTRODUCTION Temporomandibular-joint osteoarthritis (TMJOA) management is a major challenge. Minimally invasive therapies (based mainly on injections) have been developed to increase local efficacy and limit adverse systemic effects. However, the requirement for repeat injections due… read more here.
Keywords: delivery; temporomandibular joint; management; drug ... See more keywords
Neuron/Glial Antigen 2-Type VI Collagen Interactions During Murine Temporomandibular Joint Osteoarthritis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-018-37028-1
Abstract: The degeneration of articular cartilage underscores the clinical pathology of temporomandibular joint osteoarthritis (TMJ-OA) and is promoted through dysfunctional biochemical or biophysical signaling. Transduction of these signals has a multifaceted regulation that includes important cell-matrix… read more here.
Keywords: collagen interactions; temporomandibular joint; joint osteoarthritis; type ... See more keywords
Transcriptional analysis of long non-coding RNAs in facet joint osteoarthritis
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra04809f
Abstract: It is recognized that facet joint osteoarthritis (FJOA) is commonly induced by the degeneration of articular cartilage of the facet joint. However, the specific pathological mechanisms underlying facet joint osteoarthritis has not yet been elucidated.… read more here.
Keywords: facet cartilage; analysis; facet joint; joint osteoarthritis ... See more keywords
Autologous Fat Transfer for Thumb Carpometacarpal Joint Osteoarthritis: Long Term Results.
Sign Up to like & getrecommendations! Published in 2022 at "Zeitschrift fur Orthopadie und Unfallchirurgie"
DOI: 10.1055/a-1737-4541
Abstract: BACKGROUND Initial results after autologous fat transfer for treatment of thumb carpometacarpal joint osteoarthritis have been promising. But long-term results have not yet been available. METHODS In a prospective study, 42 patients with thumb carpometacarpal… read more here.
Keywords: long term; thumb; osteoarthritis; joint osteoarthritis ... See more keywords
Physical Therapist Management of Glenohumeral Joint Osteoarthritis: A Clinical Practice Guideline from the American Physical Therapy Association.
Sign Up to like & getrecommendations! Published in 2023 at "Physical therapy"
DOI: 10.1093/ptj/pzad041
Abstract: Abstract A clinical practice guideline on glenohumeral joint osteoarthritis was developed by an American Physical Therapy Association volunteer guideline development group that consisted of physical therapists, an occupational therapist, and a physician. The guideline was… read more here.
Keywords: glenohumeral joint; clinical practice; joint osteoarthritis; physical therapy ... See more keywords