Joint profiling of chromatin accessibility and CAR-T integration site analysis at population and single-cell levels
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1919259117
Abstract: Significance Chimeric antigen receptors (CARs) have established themselves as a powerful means to redirect the natural properties of T cells against tumors. However, most clinical trials fail due to limited CAR-T cell expansion. Among several… read more here.
Keywords: single cell; car integration; joint profiling; cell ... See more keywords
IL-23 skin and joint profiling in psoriatic arthritis: novel perspectives in understanding clinical responses to IL-23 inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-218186
Abstract: Objectives To determine the relationship between synovial versus skin transcriptional/histological profiles in patients with active psoriatic arthritis (PsA) and explore mechanistic links between diseased tissue pathology and clinical outcomes. Methods Twenty-seven active PsA patients were… read more here.
Keywords: psoriatic arthritis; skin joint; profiling psoriatic; joint profiling ... See more keywords