Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A, and N-Fmoc Saframycin Y3.
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DOI: 10.1021/jacs.8b07161
Abstract: The antitumor tetrahydroisoquinoline (THIQ) alkaloids share a common pentacyclic scaffold that is biosynthesized by nonribosomal peptide synthetases involving unique enzymatic Pictet-Spengler cyclizations. Herein we report concise and divergent chemo-enzymatic total syntheses of THIQ alkaloids by… read more here.
Keywords: jorunnamycin saframycin; total syntheses; enzymatic total; chemo enzymatic ... See more keywords