Deubiquitinating enzyme JOSD2 promotes hepatocellular carcinoma progression through interacting with and inhibiting CTNNB1 degradation
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11812
Abstract: Although a variety of molecular targets have been identified, hepatocellular carcinoma (HCC) remains among the leading causes of death. As functions of they deubiquitinating enzyme Josephin domain containing 2 (JOSD2) in cancers are still poorly… read more here.
Keywords: hepatocellular carcinoma; hcc; progression; deubiquitinating enzyme ... See more keywords
The deubiquitinase JOSD2 is a positive regulator of glucose metabolism.
Sign Up to like & getrecommendations! Published in 2020 at "Cell death and differentiation"
DOI: 10.1038/s41418-020-00639-1
Abstract: Cancer cells undergo complex metabolic alterations. The mechanisms underlying the tuning of cancer metabolism are under active investigation. Here, we identify the uncharacterized deubiquitinase JOSD2 as a positive regulator of cancer cell proliferation by displaying… read more here.
Keywords: deubiquitinase josd2; metabolism; josd2; positive regulator ... See more keywords
Deubiquitinating enzyme JOSD2 modulates cGAS to facilitate immune evasion in colorectal cancer.
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DOI: 10.1080/2162402x.2025.2590245
Abstract: ABSTRACT Colorectal cancer (CRC) remains a formidable clinical challenge, many patients exhibit limited responses to conventional chemotherapy and targeted therapies. Although immunotherapy has demonstrated potential, its efficacy is largely restricted to a subset of patients… read more here.
Keywords: colorectal cancer; deubiquitinating enzyme; enzyme josd2; josd2 ... See more keywords