N-Isocyanodialkylamines generated in situ for the Joullié–Ugi reaction with indolenines
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DOI: 10.1016/j.tetlet.2018.08.025
Abstract: Abstract N-Isocyanodialkylamines are rare isocyanide surrogates for the Ugi-type reactions. To avoid problems with instability and the obnoxious smell of these reagents, we optimized and employed a convenient protocol for in situ dehydration of N,N-dialkyl-N′-formyl… read more here.
Keywords: generated situ; joulli ugi; situ joulli; isocyanodialkylamines generated ... See more keywords
Diastereoselective ZnCl2-Mediated Joullié–Ugi Three-Component Reaction for the Preparation of Phosphorylated N-Acylaziridines from 2H-Azirines
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DOI: 10.3390/molecules29051023
Abstract: We disclose a direct approach to the diastereoselective synthesis of phosphorus substituted N-acylaziridines based on a one-pot ZnCl2-catalyzed Joullié–Ugi three-component reaction of phosphorylated 2H-azirines, carboxylic acids and isocyanides. Hence, this robust protocol offers rapid access… read more here.
Keywords: reaction; zncl2; component reaction; joulli ugi ... See more keywords