Abstract 6426: Novel mechanism of PIM2 inhibition leads to significant effect on solid tumors
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-6426
Abstract: Background: PIM2 is overexpressed in hematopoietic and solid cancers, and is involved in multiple signaling pathways. In hematologic malignancies, PIM2 has been shown to be a pro-survival factor and demonstrated to be a possible therapeutic… read more here.
Keywords: mechanism; treatment; inhibition; pim2 ... See more keywords
Targeting PIM2 by JP11646 results in significant antitumor effects in solid tumors
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Oncology"
DOI: 10.3892/ijo.2022.5404
Abstract: Proviral integration of Moloney virus 2 (PIM2) is a pro-survival factor of cancer cells and a possible therapeutic target in hematological malignancies. However, the attempts at inhibiting PIM2 have yielded underwhelming results in early clinical… read more here.
Keywords: jp11646; inhibitor; targeting pim2; solid tumors ... See more keywords