Liquid chromatography-tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2017.12.023
Abstract: JP4-039 radio-protects prior to, and radio-mitigates after ionizing radiation by neutralizing reactive oxygen species. We developed and validated an LC-MS/MS assay for the quantitation of JP4-039 in murine plasma. Methanol protein precipitation of 50μL plasma… read more here.
Keywords: plasma; 039 murine; jp4 039; jp4 ... See more keywords
Anti-Ferroptosis Drug Enhances Total-Body Irradiation Mitigation by Drugs that Block Apoptosis and Necroptosis
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DOI: 10.1667/rr15486.1
Abstract: Mitigation of total-body irradiation (TBI) in C57BL/6 mice by two drugs, which target apoptosis and necroptosis respectively, increases survival compared to one drug alone. Here we investigated whether the biomarker (signature)directed addition of a third… read more here.
Keywords: drug; total body; body irradiation; jp4 039 ... See more keywords
Evaluation of Different Formulations and Routes for the Delivery of the Ionizing Radiation Mitigator GS-Nitroxide (JP4-039)
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DOI: 10.21873/invivo.11341
Abstract: Background/Aim: The mitochondrial targeted GS-nitroxide, JP4-039, is an effective total body irradiation (TBI) mitigator when delivered intravenously (IV) up to 72 h after exposure. Effective systemic and localized administration to oral cavity/oropharynx and esophagus has… read more here.
Keywords: different formulations; delivery; nitroxide jp4; jp4 039 ... See more keywords
“Longitudinal Fecal Microbiome Study of Total Body Irradiated Mice Treated With Radiation Mitigators Identifies Bacterial Associations With Survival”
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.715396
Abstract: Total body irradiation (TBI) has been demonstrated to alter the intestinal microbiome, but the effects of successful small molecule ionizing radiation mitigators on the intestinal microbiome are not well-known. Our survival experiments examined the effects… read more here.
Keywords: irradiation; microbiome; mice; jp4 039 ... See more keywords