Species-specific regulation of XIST by the JPX/FTX orthologs
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad029
Abstract: Abstract X chromosome inactivation (XCI) is an essential process, yet it initiates with remarkable diversity in various mammalian species. XIST, the main trigger of XCI, is controlled in the mouse by an interplay of lncRNA… read more here.
Keywords: xist jpx; specific regulation; jpx ftx; regulation xist ... See more keywords
Abstract LB-108: A potent and selective small molecule degrader of STAT5 for the treatment of hematological malignancies
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-lb-108
Abstract: STAT5 is a member of the signal transducer and activator of transcription family of proteins and is widely recognized as an oncogenic master regulator of hematological malignancies. To date, therapeutic approaches to attenuate aberrant activity… read more here.
Keywords: potent selective; small molecule; stat5; jpx ... See more keywords
LncRNA Jpx induces Xist expression in mice using both trans and cis mechanisms
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DOI: 10.1371/journal.pgen.1007378
Abstract: Mammalian X chromosome dosage compensation balances X-linked gene products between sexes and is coordinated by the long noncoding RNA (lncRNA) Xist. Multiple cis and trans-acting factors modulate Xist expression; however, the primary competence factor responsible… read more here.
Keywords: jpx; xist expression; expression mice; lncrna jpx ... See more keywords
Knockdown of lncRNA JPX suppresses IL-1β-stimulated injury in chondrocytes through modulating an miR-25-3p/PPID axis
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Letters"
DOI: 10.3892/ol.2022.13508
Abstract: The aim of this study was to investigate the potential mechanisms of long noncoding (lnc) RNA Just proximal to X-inactive specific transcript (JPX) in interleukin (IL)-1β-stimulated chondrocytes. Human C28/I2 chondrocytes were treated with IL-1β to… read more here.
Keywords: stimulated injury; jpx knockdown; mir; injury ... See more keywords