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Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1178
Abstract: CC‐90001 selectively inhibits c‐Jun N‐terminal kinase (JNK), a stress‐activated protein implicated in fibrosis. In 3 phase 1 trials evaluating CC‐90001 pharmacokinetics, pharmacodynamics, and safety, healthy adults (N = 184) received oral CC‐90001 in a single…
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Keywords:
safety;
pharmacokinetics pharmacodynamics;
jun terminal;
phase ... See more keywords
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1
Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-75402-4_43
Abstract: c-Jun N-terminal kinase (JNK), a member of stress-induced mitogen-activated protein (MAP) kinase family, has been shown to modulate a variety of biological processes associated with neurodegenerative pathology of the retina. In particular, various retinal cell…
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Keywords:
jnk;
jun terminal;
kinase jnk;
terminal kinase ... See more keywords
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1
Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01947
Abstract: c-Jun N-terminal kinases (JNKs), members of the mitogen-activated protein kinase (MAPK) family, are encoded by three genes: jnk1, jnk2, and jnk3. JNKs are involved in the pathogenesis and development of many diseases, such as neurodegenerative…
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Keywords:
design discovery;
kinase;
jun terminal;
unraveling design ... See more keywords
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0
Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.6b01180
Abstract: The concept of covalent inhibition of c-Jun N-terminal kinase 3 (JNK3) was successfully transferred to our well validated pyridinylimidazole scaffold varying several structural features in order to deduce crucial structure-activity relationships. Joint targeting of the…
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Keywords:
pyridinylimidazoles covalent;
jun terminal;
tri tetrasubstituted;
tetrasubstituted pyridinylimidazoles ... See more keywords
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Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02318-7
Abstract: FK866 exhibits a protective effect on D-galactosamine (GaIN)/lipopolysaccharide (LPS) and concanavalin A (ConA)-induced acute liver failure (ALF), but the mechanism by which FK866 affords this benefit has not yet been elucidated. Autophagy has a protective…
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Keywords:
jnk;
jun terminal;
terminal kinase;
fk866 ... See more keywords
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1
Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20220808
Abstract: c-Jun N-terminal Kinases (JNKs) have been identified as key disease drivers in a number of pathophysiological settings and central oncogenic signaling nodes in various cancers. Their roles in driving primary tumor growth, positively regulating cancer…
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Keywords:
jnk signaling;
jun terminal;
jnk;
non kinase ... See more keywords
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1
Published in 2020 at "Journal of Investigative Surgery"
DOI: 10.1080/08941939.2019.1697401
Abstract: Abstract Objectives To investigate the bio-functions and the molecular mechanisms of NIN1/proteasome 26S subunit non-ATPase 8 binding protein 1 homolog (NOB1) in colorectal cancer cells. Methods NOB1 expression was silenced using si-RNA in SW480 and…
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Keywords:
apoptosis;
kinase;
jun terminal;
colorectal cancer ... See more keywords
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Published in 2018 at "Journal of medicinal food"
DOI: 10.1089/jmf.2017.4096
Abstract: Tannins are a type of polyphenols found in several fruits such as grapes and berries, and nuts such as aronias and acorns. Both hydrolyzable tannins and condensed tannins are referred to as tannins. Among the…
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Keywords:
kinases jun;
jun terminal;
extracellular signal;
regulated kinases ... See more keywords
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1
Published in 2017 at "Acta Physiologica"
DOI: 10.1111/apha.12758
Abstract: Prostaglandin E2 mediates sympathoexcitation in chronic heart failure (CHF) through EP3 receptors (PTGER3) in the paraventricular nucleus (PVN). The aim of this study was to investigate the role of c‐Jun N‐terminal kinase (JNK) in expressional…
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Keywords:
jun terminal;
heart failure;
terminal kinase;
chronic heart ... See more keywords
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2
Published in 2022 at "BMJ Open Respiratory Research"
DOI: 10.1136/bmjresp-2021-001060
Abstract: Introduction Idiopathic pulmonary fibrosis (IPF) is a progressive and often fatal interstitial lung disease (ILD); other ILDs have a progressive, fibrotic phenotype (PF-ILD). Antifibrotic agents can slow but not stop disease progression in patients with…
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Keywords:
week;
placebo;
jun terminal;
pulmonary fibrosis ... See more keywords
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1
Published in 2017 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2015-0195oc
Abstract: &NA; Lung tissue remodeling in chronic obstructive pulmonary disease (COPD) is characterized by airway wall thickening and/or emphysema. Although the bronchial and alveolar compartments are functionally independent entities, we recently showed comparable alterations in matrix…
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Keywords:
tnf;
jnk;
jun terminal;
tnf agr ... See more keywords