A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that Junín Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00763-17
Abstract: ABSTRACT Arenaviruses are enveloped negative-strand RNA viruses that cause significant human disease. These viruses encode only four proteins to accomplish the viral life cycle, so each arenavirus protein likely plays unappreciated accessory roles during infection.… read more here.
Keywords: junv; jun virus; host; pkr ... See more keywords
Junín virus induces autophagy in human A549 cells
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DOI: 10.1371/journal.pone.0218730
Abstract: Autophagy, a highly regulated degradative process that promotes cellular homeostasis, is increasingly recognised as a fundamental component of the cellular response against viral infection. In this study, we investigated the role of autophagy during Junín… read more here.
Keywords: a549 cells; jun virus; infection; human a549 ... See more keywords
Modulation of the Aryl Hydrocarbon Receptor Signaling Pathway Impacts on Junín Virus Replication
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DOI: 10.3390/v15020369
Abstract: Junín virus (JUNV), a member of the family Arenaviridae, is the etiological agent of the Argentine hemorrhagic fever, an endemic disease in the rural region of Argentina lacking a specific chemotherapy. Aryl hydrocarbon receptor (AHR)… read more here.
Keywords: hydrocarbon receptor; signaling pathway; modulation; jun virus ... See more keywords
Immunization with GP1 but Not Core-like Particles Displaying Isolated Receptor-Binding Epitopes Elicits Virus-Neutralizing Antibodies against Junín Virus
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DOI: 10.3390/vaccines10020173
Abstract: New World arenaviruses are rodent-transmitted viruses and include a number of pathogens that are responsible for causing severe human disease. This includes Junín virus (JUNV), which is the causative agent of Argentine hemorrhagic fever. The… read more here.
Keywords: receptor binding; gp1; neutralizing antibodies; core like ... See more keywords