Automaticity in ventricular myocyte cell pairs with ephaptic and gap junction coupling.
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DOI: 10.1063/5.0085291
Abstract: Spontaneous electrical activity, or automaticity, in the heart is required for normal physiological function. However, irregular automaticity, in particular, originating from the ventricles, can trigger life-threatening cardiac arrhythmias. Thus, understanding mechanisms of automaticity and synchronization… read more here.
Keywords: junction coupling; gap junction; automaticity; cell pairs ... See more keywords
Modulation of Gap Junction Coupling Within the Islet of Langerhans During the Development of Type 1 Diabetes
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DOI: 10.3389/fphys.2022.913611
Abstract: In type 1 diabetes (T1D), islet dysfunction occurs prior to diabetes onset. Pro-inflammatory cytokines can disrupt insulin secretion and Ca2+ homeostasis. Connexin36 (Cx36) gap junctions electrically couple β-cells to coordinate glucose-stimulated Ca2+ and insulin secretion.… read more here.
Keywords: cx36; junction coupling; gap junction; islet ... See more keywords