Blood-Brain Barrier Permeability Is Exacerbated in Experimental Model of Hepatic Encephalopathy via MMP-9 Activation and Downregulation of Tight Junction Proteins
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0521-7
Abstract: The present study was designed to investigate the mechanisms involved in blood-brain barrier (BBB) permeability in bile duct ligation (BDL) model of chronic hepatic encephalopathy (HE). Four weeks after BDL surgery, a significant increase was… read more here.
Keywords: bdl rats; permeability; expression; junction proteins ... See more keywords
Cell junction proteins: Crossing the glomerular filtration barrier in diabetic nephropathy.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.01.168
Abstract: Diabetic nephropathy as a deleterious complication of diabetes mellitus and an important cause of end-stage renal failure is characterized by changes in the molecular and cellular levels. Cell-cell communication via the gap and tight junctions… read more here.
Keywords: proteins crossing; cell junction; diabetic nephropathy; crossing glomerular ... See more keywords
Oxidative stress mediates heat-induced changes of tight junction proteins in porcine sertoli cells via inhibiting CaMKKβ-AMPK pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2019.09.031
Abstract: Heat stress causes reversible changes in tight junction proteins in immature Sertoli cells via inhibition of the AMPK signaling pathway; these effects are accompanied by an increase in the early apoptotic rate and decrease in… read more here.
Keywords: heat stress; sertoli cells; stress; heat ... See more keywords
MicroRNAs-143 and -145 induce epithelial to mesenchymal transition and modulate the expression of junction proteins
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.103
Abstract: Transforming growth factor (TGF)-β is one of the major inducers of epithelial to mesenchymal transition (EMT), a crucial program that has a critical role in promoting carcinoma’s metastasis formation. MicroRNAs-143 and -145, which are both… read more here.
Keywords: epithelial mesenchymal; expression; role; 143 145 ... See more keywords
Analysis of differential expression of tight junction proteins in cultured oral epithelial cells altered by Porphyromonas gingivalis, Porphyromonas gingivalis lipopolysaccharide, and extracellular adenosine triphosphate
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Oral Science"
DOI: 10.1038/ijos.2017.51
Abstract: Tight junctions (TJs) are the most apical intercellular junctions of epithelial cells formed by occludin, claudins, junctional adhesion molecules (JAMs), and zonula occludens (ZO). Tight junction proteins can sense the presence of bacteria and regulate… read more here.
Keywords: claudin; porphyromonas gingivalis; gingivalis; junction proteins ... See more keywords
Comparison of astrocytes and gap junction proteins in the white matter of genetic absence epileptic and control rats: an experimental study
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Research"
DOI: 10.1080/01616412.2022.2039527
Abstract: ABSTRACT Objectives The role of white matter astrocytes in absence epilepsy is unknown. The present study aims to quantify astrocytic markers glial fibrillary acidic protein (GFAP), gap junction’s proteins connexin 30 (Cx30) and connexin 43… read more here.
Keywords: gap junction; white matter; junction proteins; control ... See more keywords
Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression
Sign Up to like & getrecommendations! Published in 2019 at "Brain"
DOI: 10.1093/brain/awz011
Abstract: While the accumulation and aggregation of amyloid-β and tau are central events in the pathogenesis of Alzheimer's disease, there is increasing evidence that cerebrovascular pathology is also abundant in Alzheimer's disease brains. In brain capillaries,… read more here.
Keywords: alzheimer disease; disease; junction proteins; brain ... See more keywords
Effect of Helicobacter pylori infection and its eradication on the expression of tight junction proteins in the gastric epithelium in relation to gastric carcinogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Helicobacter"
DOI: 10.1111/hel.12929
Abstract: Tight junction proteins (TJPs) play a role in epithelial defense mechanisms. However, the effect of Helicobacter pylori (Hp) on TJPs remains unclear. This study aimed to evaluate the expression of TJPs in relation to Hp… read more here.
Keywords: tight junction; junction proteins; helicobacter; effect helicobacter ... See more keywords
Tight junction proteins occludin and ZO‐1 as regulators of epithelial proliferation and survival
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14798
Abstract: Epithelial cells are the first line of mucosal defense. In the intestine, a single layer of epithelial cells must establish a selectively permeable barrier that supports nutrient absorption and waste secretion while preventing the leakage… read more here.
Keywords: proteins occludin; proliferation; tight junction; junction proteins ... See more keywords
Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway
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DOI: 10.1371/journal.pone.0179586
Abstract: The intestinal epithelial barrier, composed of epithelial cells, tight junction proteins and intestinal secretions, prevents passage of luminal substances and antigens through the paracellular space. Dysfunction of the intestinal barrier integrity induced by toxins and… read more here.
Keywords: barrier; butyrate; intestinal barrier; junction proteins ... See more keywords
Disruption of the pro-inflammatory, anti-inflammatory cytokines and tight junction proteins expression, associated with changes of the composition of the gut microbiota in patients with irritable bowel syndrome
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0252930
Abstract: Background Irritable bowel syndrome (IBS) is a pathologic condition characterized by changes in gut microbiome composition, low-grade inflammation, and disruption of intestinal wall permeability. The interaction between the gut microbiome and the disease manifestation remains… read more here.
Keywords: inflammatory; expression; junction proteins; ibs patients ... See more keywords