Prooxidant effects of synthetic cannabinoids on endometrial cells, results in a strenous rebound adaptative effect
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.442
Abstract: Synthetic cannabinoids (SCs) are easily available and their use as recreational drugs has increased over the years. It is known that the endocannabinoid system plays an important role in early pregnancy. Here, we assessed whether… read more here.
Keywords: synthetic cannabinoids; jwh; effects synthetic; endometrial cells ... See more keywords
Novel halogenated synthetic cannabinoids impair sensorimotor functions in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2019.10.002
Abstract: JWH-018-Cl, JWH-018-Br and AM-2201 (JWH-018 halogenated-derivatives; JWH-018-R compounds) are synthetic cannabinoid agonists illegally marketed as "Spice", "K2", "herbal blend" and research chemicals for their cannabis-like psychoactive effects. In rodents, JWH-018 and its halogenated derivatives reproduce… read more here.
Keywords: jwh 018; synthetic cannabinoids; jwh; sensorimotor functions ... See more keywords
Effects of synthetic (JWH-018) cannabinoids treatment on spermatogenesis and sperm function.
Sign Up to like & getrecommendations! Published in 2019 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2019.1680686
Abstract: JWH-018 is a synthetic cannabinoid which has been increasingly used by adolescents and adults, and is known to cause severe multi-organ failure. However, little is known about the complications and toxicological effects of JWH-018 on… read more here.
Keywords: spermatogenesis; jwh 018; testis; jwh ... See more keywords
Nausea-Induced Conditioned Gaping Reactions in Rats Produced by High-Dose Synthetic Cannabinoid, JWH-018.
Sign Up to like & getrecommendations! Published in 2020 at "Cannabis and cannabinoid research"
DOI: 10.1089/can.2019.0103
Abstract: Introduction: Cannabinoid hyperemesis syndrome is becoming a more prominently reported side effect of cannabis containing high-dose Δ9-tetrahydrocannabinol (THC) and designer cannabinoid drugs such as "Spice." One active ingredient that has been found in "Spice" is… read more here.
Keywords: jwh 018; jwh; high dose; nausea ... See more keywords
Effects of Δ9-Tetrahydrocannabinol and the Aminoalkylindole K2/Spice Constituent JWH-073 on Cardiac Tissue and Mesenteric Vascular Reactivity.
Sign Up to like & getrecommendations! Published in 2023 at "Cannabis and cannabinoid research"
DOI: 10.1089/can.2022.0325
Abstract: Background: Although use of Cannabis sativa is not associated with serious adverse effects, recreational use of aminoalkylindole (AAI) cannabinoid receptor agonists found in K2/Spice herbal blends has been reported to cause adverse cardiovascular events, including… read more here.
Keywords: mesenteric vascular; vascular reactivity; jwh; 073 thc ... See more keywords
In vitro assessment of the cytotoxic, genotoxic and oxidative stress effects of the synthetic cannabinoid JWH-018 in human SH-SY5Y neuronal cells.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology research"
DOI: 10.1093/toxres/tfaa078
Abstract: BACKGROUND JWH-018 was the first synthetic cannabinoid introduced as a legal high and the first of the new generation of novel psychoactive substances that flooded worldwide drug markets. JWH-018 was marketed as "spice," "herbal incense,"… read more here.
Keywords: jwh 018; neuronal cells; jwh; synthetic cannabinoid ... See more keywords
Repeated Exposure to the “Spice” Cannabinoid JWH-018 Induces Tolerance and Enhances Responsiveness to 5-HT1A Receptor Stimulation in Male Rats
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2018.00055
Abstract: Naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) is a synthetic compound found in psychoactive “spice” products that activates cannabinoid receptors. Preclinical evidence suggests that exposure to synthetic cannabinoids increases 5-HT2A/2C receptor function in the brain, an effect which might contribute… read more here.
Keywords: jwh 018; treatment; ht1a receptor; jwh ... See more keywords
In Vivo Bio-Activation of JWH-175 to JWH-018: Pharmacodynamic and Pharmacokinetic Studies in Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23148030
Abstract: 3-(1-Naphthalenylmethyl)-1-pentyl-1H-indole (JWH-175) is a synthetic cannabinoid illegally marketed for its psychoactive cannabis-like effects. This study aimed to investigate and compare in vitro and in vivo pharmacodynamic activity of JWH-175 with that of 1-naphthalenyl (1-pentyl-1H-indol-3-yl)-methanone (JWH-018),… read more here.
Keywords: bio activation; jwh 018; jwh; vivo bio ... See more keywords