Pharmacokinetic properties of the synthetic cannabinoid JWH-018 in oral fluid after inhalation.
Sign Up to like & getrecommendations! Published in 2018 at "Drug testing and analysis"
DOI: 10.1002/dta.2310
Abstract: Each year, synthetic cannabinoids occur in high numbers on the illicit drug market, but data on their detectability are rarely available. A pilot study was performed to assess adverse effects of JWH-018, which is one… read more here.
Keywords: jwh 018; oral fluid; fluid; drug ... See more keywords
Liquid chromatography–mass spectrometry studies on the isomeric 1-fluorobenzyl-3-naphthoyl-indoles: FUB-JWH-018 and five isomers
Sign Up to like & getrecommendations! Published in 2018 at "Forensic Toxicology"
DOI: 10.1007/s11419-018-0442-9
Abstract: PurposeOne of the ongoing research subjects for forensic analysts is differentiating halogen positional isomers of newly-emerging synthetic cannabinoids. The purpose of this study is to elucidate liquid chromatographic and mass spectrometric conditions applicable to the… read more here.
Keywords: jwh 018; mass spectrometry; mass; ion ... See more keywords
Interactions between opioids and cannabinoids: Economic demand for opioid/cannabinoid mixtures.
Sign Up to like & getrecommendations! Published in 2020 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2020.108043
Abstract: BACKGROUND Opioid abuse remains a significant public health challenge. With continuing emergence of novel psychoactive substances (e.g., synthetic cannabinoids found in "K2" or "spice" preparations), the co-administration of opioids and other novel drugs is likely… read more here.
Keywords: jwh 018; cannabinoid mixtures; economic demand; opioid cannabinoid ... See more keywords
Rapid and sensitive detection of synthetic cannabinoids JWH-018, JWH-073 and their metabolites using molecularly imprinted polymer-coated QCM nanosensor in artificial saliva
Sign Up to like & getrecommendations! Published in 2020 at "Microchemical Journal"
DOI: 10.1016/j.microc.2019.104454
Abstract: Abstract Synthetic cannabinoids (SCs), which are becoming increasingly popular, are an important public health issue considering the common abuse uses and serious adverse effects associated with intoxication. The analysis for controlling the increase in synthetic… read more here.
Keywords: jwh 018; detection; synthetic cannabinoids; jwh 073 ... See more keywords
Novel halogenated synthetic cannabinoids impair sensorimotor functions in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2019.10.002
Abstract: JWH-018-Cl, JWH-018-Br and AM-2201 (JWH-018 halogenated-derivatives; JWH-018-R compounds) are synthetic cannabinoid agonists illegally marketed as "Spice", "K2", "herbal blend" and research chemicals for their cannabis-like psychoactive effects. In rodents, JWH-018 and its halogenated derivatives reproduce… read more here.
Keywords: jwh 018; synthetic cannabinoids; jwh; sensorimotor functions ... See more keywords
Effects of synthetic (JWH-018) cannabinoids treatment on spermatogenesis and sperm function.
Sign Up to like & getrecommendations! Published in 2019 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2019.1680686
Abstract: JWH-018 is a synthetic cannabinoid which has been increasingly used by adolescents and adults, and is known to cause severe multi-organ failure. However, little is known about the complications and toxicological effects of JWH-018 on… read more here.
Keywords: spermatogenesis; jwh 018; testis; jwh ... See more keywords
The control of synthetic cannabinoids potentiates the toxicity of emerging substances
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Medicine"
DOI: 10.1080/07853890.2018.1562139
Abstract: Introduction: Novel psychoactive substances (NPS) is becoming a major public health concern as their use grows. In the EU, synthetic cannabinoids (SC) are the most frequently reported class of NPS. SC are widely distributed as… read more here.
Keywords: jwh 018; synthetic cannabinoids; viability; control ... See more keywords
Nausea-Induced Conditioned Gaping Reactions in Rats Produced by High-Dose Synthetic Cannabinoid, JWH-018.
Sign Up to like & getrecommendations! Published in 2020 at "Cannabis and cannabinoid research"
DOI: 10.1089/can.2019.0103
Abstract: Introduction: Cannabinoid hyperemesis syndrome is becoming a more prominently reported side effect of cannabis containing high-dose Δ9-tetrahydrocannabinol (THC) and designer cannabinoid drugs such as "Spice." One active ingredient that has been found in "Spice" is… read more here.
Keywords: jwh 018; jwh; high dose; nausea ... See more keywords
Investigating the Effects of a Synthetic Cannabinoid on the Pathogenesis of Leukemia and Leukemic Stem Cells: A New Therapeutic Approach.
Sign Up to like & getrecommendations! Published in 2022 at "Cannabis and cannabinoid research"
DOI: 10.1089/can.2021.0180
Abstract: The popularity and usage of synthetic cannabinoids (SCs) are increasing due to their easy accessibility and psychoactive effects worldwide. Studies on cannabinoids on leukemic stem cells (LSC) and hematopoietic stem cells (HSCs), which are the… read more here.
Keywords: jwh 018; therapeutic approach; leukemia; leukemic stem ... See more keywords
In vitro assessment of the cytotoxic, genotoxic and oxidative stress effects of the synthetic cannabinoid JWH-018 in human SH-SY5Y neuronal cells.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology research"
DOI: 10.1093/toxres/tfaa078
Abstract: BACKGROUND JWH-018 was the first synthetic cannabinoid introduced as a legal high and the first of the new generation of novel psychoactive substances that flooded worldwide drug markets. JWH-018 was marketed as "spice," "herbal incense,"… read more here.
Keywords: jwh 018; neuronal cells; jwh; synthetic cannabinoid ... See more keywords
Deletion of Cryab increases the vulnerability of mice to the addiction-like effects of the cannabinoid JWH-018 via upregulation of striatal NF-κB expression
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1135929
Abstract: Synthetic cannabinoids have exhibited unpredictable abuse liabilities, especially self-administration (SA) responses in normal rodent models, despite seemingly inducing addiction-like effects in humans. Thus, an efficient pre-clinical model must be developed to determine cannabinoid abuse potential… read more here.
Keywords: addiction like; jwh 018; cryab; cryab mice ... See more keywords