Mechanisms of cannabinoid CB2 receptor-mediated reduction of dopamine neuronal excitability in mouse ventral tegmental area
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.03.040
Abstract: Background We have recently reported that activation of cannabinoid type 2 receptors (CB2Rs) reduces dopamine (DA) neuron excitability in mouse ventral tegmental area (VTA). Here, we elucidate the underlying mechanisms. Methods Patch-clamp recordings were performed… read more here.
Keywords: vta; reduction; excitability mouse; jwh133 ... See more keywords
Cannabinoid type 2 receptor agonist JWH133 decreases blood pressure of spontaneously hypertensive rats through relieving inflammation in the rostral ventrolateral medulla of the brain.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000002342
Abstract: OBJECTIVE Neuroinflammation in the rostral ventrolateral medulla (RVLM) has been reported to be associated with hypertension. The upregulation and activation of the cannabinoid type 2 (CB2) receptor may be part of the active process of… read more here.
Keywords: jwh133; cb2 receptor; rvlm; receptor ... See more keywords